PMID: 6108727Jul 1, 1980Paper

Inhibition by ketotifen of idiosyncratic reactions to aspirin

Allergy
A SzczeklikP Kuklinski

Abstract

Ketotifen administered prior to aspirin offered protection against bronchoconstriction in 13 of 14 patients with aspirin-sensitive asthma. In four other subjects, suffering from urticaria/angioedema following ingestion of aspirin-like drugs, pretreatment with ketotifen resulted in total prevention of the adverse reactions. These results support the suggestion of a common pathogenetic mechanism operating in two distinct clinical patterns of idiosyncrasy to aspirin and other cyclo-oxygenase inhibitors. They also indicate that ketotifen might find application in treatment of adverse reactions to aspirin.

References

May 1, 1978·Clinical Allergy·R PauwelsM Van Der Straeten
Nov 1, 1977·The Journal of Allergy and Clinical Immunology·A SzczeklikG Czerniawska-Mysik
Sep 1, 1976·Clinical Allergy·D D StevensonE M Tan

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Citations

Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Sclano
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·A R FischerJ M Drazen
Oct 1, 1982·Clinical Allergy·J O Warner, S J Goldsworthy

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