PMID: 6408306Jan 1, 1983Paper

Inhibition by L-phenylalanine of tryptophan transport by synaptosomal plasma membrane vesicles: implications in the pathogenesis of phenylketonuria

Journal of Inherited Metabolic Disease
E HerreroF Valdivieso

Abstract

Phenylalanine is accumulated in the genetically linked deficiency phenylketonuria. The effect of L-phenylalanine on the transport of tryptophan was studied using membrane vesicles from rat-brain synaptosomes. Phenylalanine at similar concentrations to those found in phenylketonuric patients competitively inhibits tryptophan uptake, with a Ki of the same order as the Km for tryptophan. This inhibition could be responsible for the depletion of serotonin found in phenylketonuria.

References

Jan 1, 1976·Advances in Experimental Medicine and Biology·O E Pratt
Jun 1, 1979·Neurochemical Research·M L Laakso, S S Oja
Dec 19, 1977·Experimental Brain Research·P Lähdesmäki, M L Hannus
Sep 1, 1970·Journal of Neurochemistry·D G Grahame-Smith, A G Parfitt
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·C V VorheesH K Berry
Sep 7, 1981·Biochimica Et Biophysica Acta·M C AragónF Valdivieso
Sep 15, 1981·The Biochemical Journal·F MayorF Valdivieso
Dec 1, 1981·Journal of Neurochemistry·J G MarvizónF Valdivieso
Jul 16, 1980·Biochimica Et Biophysica Acta·B I Kanner, I Sharon

❮ Previous
Next ❯

Citations

Jan 1, 1987·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·A LandiM Giovannini
Jan 1, 1988·Journal of Inherited Metabolic Disease·M GiovanniniG B Picotti
Jan 1, 1988·Journal of Inherited Metabolic Disease·M GiovanniniR Longhi
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stylianos TsakirisPanagiotis Behrakis
Oct 6, 2000·Clinical Biochemistry·C PlatarasP Angelogianni
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Charalambos AntoniadesStylianos Tsakiris
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Haris CarageorgiouStylianos Tsakiris
Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kellen R SimonPatrícia F Schuck
Dec 15, 2007·Journal of Child Neurology·Barbara ManziPaolo Curatolo
Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Elena Rodríguez RodríguezCarlos Díaz Romero
Aug 1, 1988·Journal of Mental Deficiency Research·S Missiou-TsagarakiM Loumakou
May 10, 2005·Biochimica Et Biophysica Acta·L R SirtoriC R Vargas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.