PMID: 6328335Mar 1, 1984

Inhibition by loperamide of deoxycholic acid induced intestinal secretion

Naunyn-Schmiedeberg's Archives of Pharmacology
U M Farack, K Loeschke

Abstract

The effect of loperamide on deoxycholic acid (DOC)-induced secretion was studied in ligated loops of the rat jejunum and colon in vivo. In controls, loperamide slightly augmented fluid absorption. 3 mmol DOC caused net fluid secretion. Loperamide reduced this secretion in the colon and reversed it to absorption in the jejunum. Na-K-ATPase specific activity and cAMP levels were measured in the jejunum, and [14C]erythritol clearance as an index of mucosal permeability in the colon. In the jejunum this opiate analogue affected neither basal or DOC-depressed Na-K-ATPase, nor mucosal cAMP. In the colon it reduced a large increase of the erythritol clearance caused by DOC. It is suggested that loperamide interferes with DOC-induced intestinal secretion in part by lowering mucosal permeability.

References

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Citations

Jul 1, 1989·Pflügers Archiv : European journal of physiology·F WehnerK U Petersen
Nov 1, 1989·Digestive Diseases and Sciences·C M VázquezA Ilundaín
Oct 24, 1989·European Journal of Pharmacology·K LoeschkeU M Farack
Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Feb 24, 2001·Annals of the New York Academy of Sciences·D Wermelskirchen, K Schneider
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen

Related Concepts

Cyclic AMP, (R)-Isomer
Na(+)-K(+)-Exchanging ATPase
Taenia Coli
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Erythritol
Intestinal Absorption
Structure of Intestinal Gland
Intestinal Secretions
Jejunum
Imodium

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