PMID: 11311427Apr 20, 2001Paper

Inhibition by prostaglandin PGA1 on the multiplication of influenza virus is a dose-dependent effect

Virus Research
G ContiC Chezzi

Abstract

Cyclopentenone prostaglandins (PGs), are strong inhibitors of the multiplicative cycle of a wide variety of enveloped RNA and DNA viruses. Their antiviral activity is generally associated with alterations in the synthesis or maturation of specific virus proteins. In this report, we describe the effect of cyclopentenone PGA1 on the replication of influenza A virus Ulster 73 in LLC-MK2 cells. PGA1 was found to inhibit viral replication in a dose-dependent fashion and virus particle yield was reduced at a PGA1 concentration, which did not suppress protein synthesis in mock-infected cells. The kinetic of late viral protein synthesis was delayed in PGA1-treated cells till 10 h post-infection; after that period, viral polypeptide synthesis appeared to be similar in PGA1-treated as well as untreated cells both infected by Ulster 73 virus. This finding suggests that PGA1 might interfere with one or more events in the viral multiplicative cycle such as protein synthesis and assembly, correct insertion of virus polypeptides into the cell membrane and, or maturation of Ulster 73 virion particles. In particular, inhibition of viral replication in LLC-MK2 cells by PGA1 is accompanied by the induction of a cellular polypeptide of 70K molecul...Continue Reading

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Citations

Mar 21, 2006·Biochemistry. Biokhimii︠a︡·A I Hubich, M V Sholukh
Dec 13, 2006·Journal of Insect Physiology·Ender BüyükgüzelKemal Büyükgüzel
May 29, 2015·Archives of Virology·Shashank TripathiSunil K Lal
Aug 3, 2021·Frontiers in Physiology·Bohae Rachel LeeNeelam Sharma-Walia

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