PMID: 8584249Oct 20, 1995Paper

Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury

Neuroscience Letters
M H OssipovF Porreca

Abstract

Nerve ligation injury in rats produces increased sensitivity and exaggerated responses to nociceptive stimuli (hyperalgesia) as well as nociceptive responses to normally innocuous stimuli (allodynia) analogous to clinical conditions of neuropathic pain. However, the effect of nerve injury on acute nociception has not been extensively studied. Nerve ligation injury was produced by unilateral ligation of the L5 and L6 spinal roots of the sciatic nerve of male Sprague-Dawley rats. Intrathecal (i.th.) catheters were inserted for spinal drug administration. Response to acute nociception was measured by determining the latency to a rapid flick of the tail (TF) after immersion into a 55 degrees C water bath before (control) and after i.th. morphine administration. No change in baseline response to the nociceptive stimulus was observed in either sham-operated or nerve-injured rats. In sham-operated rats, morphine produced dose-dependent antinociception with a 97 +/- 2.3% maximal possible effect (MPE) at a 60 microgram dose; in these controls A50 (95% CL) was 22 micrograms (17-30 micrograms). Morphine administered to rats with nerve injury also produced dose-dependent increase in TF latency, but an MPE of only 60 +/- 17% was obtained at...Continue Reading

References

Apr 1, 1979·The Journal of Comparative Neurology·K ChungR E Coggeshall
May 1, 1991·Canadian Journal of Physiology and Pharmacology·G F Gebhart, T J Ness
Mar 1, 1994·Trends in Pharmacological Sciences·L StanfaZ Wiesenfeld-Hallin
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

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Citations

Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Aug 15, 2002·European Journal of Pharmacology·Poli Francois KouyaXiao-Jun Xu
Mar 17, 1999·European Journal of Pharmacology·B PrzewłockaR Przewłocki
Jul 8, 2000·Neuropharmacology·D E Womer, H E Shannon
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·J J RadyJ M Fujimoto
Jun 28, 2002·Trends in Neurosciences·Frank PorrecaG F Gebhart
Jun 12, 2003·Behavioural Brain Research·Ian N Johnston, R Frederick Westbrook
Sep 22, 2000·Peptides·T D MoranP A Smith
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M Sahebgharani, M Zarrindast
Apr 12, 2003·Pharmacology & Toxicology·Zsuzsanna Wiesenfeld-HallinTomas Hökfelt
Oct 23, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Toyokazu TsuchiharaHiroshi Arino
Dec 1, 1996·Anaesthesia·C C MayneR Munglani
Feb 17, 2000·Annals of the New York Academy of Sciences·R PrzewłockiG Toth
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·D M CainD A Simone
Jun 7, 2011·European Journal of Pharmacology·Thomas ChristophThomas M Tzschentke
Mar 27, 2007·Behavioural Brain Research·Michelle A HookJames W Grau
Jul 22, 2009·Neuroscience Letters·Junesun KimYoung Wook Yoon
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Joanna MikaBarbara Przewlocka
Feb 21, 2006·The European Journal of Neuroscience·Xavier NadalRafael Maldonado
Mar 20, 2014·British Journal of Pharmacology·A-J Chabot-DoréG L Wilcox
Jun 28, 2007·Expert Opinion on Investigational Drugs·Annemarie LedeboerKirk W Johnson

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