Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro

Journal of Autonomic Pharmacology
C Wilson

Abstract

1. The effects of the sulphonylureas glibenclamide, glipizide and tolbutamide on relaxant responses to the K+ channel activator, cromakalim (BRL 34915), were investigated in rabbit isolated mesenteric artery. The interaction between glibenclamide and pinacidil, another K+ channel activator, was also studied. 2. Glibenclamide produced progressive parallel shifts to the right of the cromakalim and pinacidil concentration-response curves. The calculated pA2 values were 7.16 +/- 0.03 against cromakalim and 6.66 +/- 0.05 against pinacidil. 3. Glipizide and tolbutamide also produced parallel shifts to the right of the cromakalim concentration-response curve to yield pA2 values of 5.59 and 3.98 respectively. 4. Glibenclamide had little inhibitory effect upon vasorelaxant responses to the Ca2+ channel blocker, nifedipine. 5. The results suggest that cromakalim and pinacidil activate an ATP-sensitive K+ channel in vascular smooth muscle which may differ from that of the pancreatic beta-cells.

References

Jul 15, 1987·Biochemical and Biophysical Research Communications·H Schmid-AntomarchiM Lazdunski
Jan 1, 1988·Journal of Cardiovascular Pharmacology·N S CookC Pally
Sep 1, 1987·Journal of Autonomic Pharmacology·J C Clapham, C Wilson
Oct 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·R FerrerE Rojas

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Citations

Nov 1, 1989·Pflügers Archiv : European journal of physiology·M Wahl
Nov 6, 1990·European Journal of Pharmacology·J LongmoreA H Weston
Jun 23, 1995·European Journal of Pharmacology·A JovanovićS Jovanović
Jan 1, 1996·Pharmacology & Therapeutics·K Lawson
Mar 1, 1993·General Pharmacology·G A McPherson
Apr 29, 1998·British Journal of Pharmacology·R Barrett-Jolley, G A McPherson
Jul 1, 1993·Clinical and Experimental Pharmacology & Physiology·J L Challinor, G A McPherson
Jan 1, 1997·Fundamental & Clinical Pharmacology·L Gojkoviíc BukaricaM Bojić
Dec 1, 1990·British Journal of Pharmacology·I PiperH Sadraei
May 1, 1991·British Journal of Pharmacology·K MasuzawaM Asano
Jan 1, 1992·British Journal of Pharmacology·S J Downing, M Hollingsworth
May 1, 1989·British Journal of Pharmacology·R E BuckinghamC Wilson
Aug 7, 2002·Biochemical and Biophysical Research Communications·Kun CaoRui Wang
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A A ParsonsM Wahl
Oct 26, 1991·BMJ : British Medical Journal·M H Beck
Oct 26, 1991·BMJ : British Medical Journal·R Walden
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·N W DavisP R Stanfield

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