Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1.

The Journal of Biological Chemistry
Varpu EleniusM Bernfield

Abstract

Wound repair is a tightly regulated process stimulated by proteases, growth factors, and chemokines, which are modulated by heparan sulfate. To characterize further the role of the heparan sulfate proteoglycan syndecan-1 in wound repair, we generated mice overexpressing syndecan-1 (Snd/Snd) and studied dermal wound repair. Wound closure, reepithelialization, granulation tissue formation, and remodeling were delayed in Snd/Snd mice. Soluble syndecan-1 was increased, and shedding was prolonged in wounds from Snd/Snd mice. Excess syndecan-1 increased the elastolytic activity of wound fluids. Additionally, cells in the granulation tissue and keratinocytes at wound edges showed markedly reduced proliferation rates in Snd/Snd mice. Skin grafting experiments between Snd/Snd and control mice indicated that the slower growth rate was mainly due to a soluble factor in the Snd/Snd mouse skin. Syndecan-1 immunodepletion and further degradation experiments identified syndecan-1 ectodomain as a dominant negative inhibitor of cell proliferation. These studies indicate that shed syndecan-1 ectodomain may enhance proteolytic activity and inhibit cell proliferation during wound repair.

References

Aug 1, 1991·The Journal of Cell Biology·K EleniusM Jalkanen
Dec 1, 1990·The Journal of Investigative Dermatology·P A HebdaJ C Fiddes
Jul 1, 1990·The Journal of Experimental Medicine·R Tsuboi, D B Rifkin
Apr 1, 1987·The Journal of Investigative Dermatology·S MoriokaP J Jensen
Jul 1, 1994·The Journal of Clinical Investigation·U K Saarialho-KereH G Welgus
Mar 1, 1994·The Journal of Surgical Research·N S GibranD Gordon
Mar 1, 1996·Nature Medicine·J RomerK Dano
Aug 2, 1996·The Journal of Biological Chemistry·V KainulainenK Elenius
Nov 1, 1996·The Journal of Investigative Dermatology·R GalloM Bernfield
Dec 1, 1996·Cytokine & Growth Factor Reviews·M Goldfarb
Jun 6, 1997·The Journal of Biological Chemistry·S V SubramanianM Bernfield
Jun 13, 1998·The Journal of Biological Chemistry·V KainulainenM Bernfield
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S OrtegaC Basilico
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Nov 29, 2001·The Journal of Cell Biology·B L AllenA C Rapraeger
Nov 5, 2002·Journal of Cell Science·Mary Ann SteppMerton Bernfield
Jan 22, 2003·The Journal of Investigative Dermatology·Alice H M BeareMark W J Ferguson
Apr 1, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin Götte
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Jul 9, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elizabeth A Baker, David J Leaper

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Citations

Apr 4, 2008·Archives of Dermatological Research·Davor TomasBozo Kruslin
Oct 9, 2013·Molecular and Cellular Biochemistry·Neeta AdhikariJennifer L Hall
Aug 19, 2006·Nature Reviews. Immunology·Christopher R Parish
Nov 1, 2007·Nature Reviews. Molecular Cell Biology·Mark R MorganMark D Bass
Dec 17, 2008·The Journal of Biological Chemistry·Corrine R KlimentTim D Oury
Jun 3, 2005·Molecular Biology of the Cell·Ritu ChakravartiJosephine C Adams
Mar 3, 2009·American Journal of Respiratory Cell and Molecular Biology·Stanley C H ChanDaisy K Y Shum
Jul 25, 2009·Cellular and Molecular Life Sciences : CMLS·Catherine Kirn-SafranDaniel D Carson
May 2, 2007·The Journal of Cell Biology·Mark M FusterJeffrey D Esko
Sep 7, 2007·Kidney International·A L RopsJ van der Vlag
Jul 13, 2007·The Journal of Investigative Dermatology·Nkemcho OjehArto Määttä
Oct 14, 2005·EMBO Reports·Anthony H Merry, Catherine L R Merry
May 10, 2007·Journal of Cellular and Molecular Medicine·John M Rhodes, Michael Simons
Sep 16, 2010·The FEBS Journal·Tina Manon-JensenJohn R Couchman
May 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nicole C SmitsToin H van Kuppevelt
Dec 30, 2014·International Journal of Experimental Pathology·John R CouchmanHinke A B Multhaupt
Aug 29, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Constance Y Fears, Anne Woods
Sep 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nabil Mohie Abdel-HamidA S Gerges
Sep 25, 2012·Toxicology and Applied Pharmacology·Huiying ZhangPhilip L Sannes
Aug 9, 2011·Molecular and Cellular Neurosciences·Suvarna Dash-WaghPetra Wahle
Oct 2, 2007·Journal of Vascular Surgery·Jing WenElliot L Chaikof
May 7, 2015·Advances in Wound Care·Mary Ann SteppAhdeah Pajoohesh-Ganji
Nov 14, 2006·The International Journal of Biochemistry & Cell Biology·Annika N AlexopoulouJohn R Couchman
Feb 3, 2015·Frontiers in Physiology·Anna FilatovaThimios A Mitsiadis
Jul 2, 2016·Cell and Tissue Research·Zoi PiperigkouMartin Götte
Nov 27, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Yoshio ShimabukuroShinya Murakami
Jan 1, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Julianty AngsanaElliot L Chaikof
Mar 19, 2005·Circulation Research·Eugene TkachenkoMichael Simons
Aug 24, 2006·The Journal of Biological Chemistry·Myung-Chul ChungSerguei G Popov
Jul 24, 2014·The Journal of Biological Chemistry·Vivien Jane Coulson-ThomasWinston Kao

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