Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition

Journal of Pharmacological Sciences
Xiaoyu ZhangYuhong Bian

Abstract

Glycyrrhiza Uralensis Polysaccharide (GCP), as a macromolecular polysaccharide extracted from the Traditional Chinese Medicine (TCM) - Licorice has been proved to inhibit tumor growth in vitro and in vivo; however, the specific anti-tumor mechanism of GCP needs to be further investigated. In this study, we explore the anti-tumor mechanism of GCP from the angle of gut microbiota. Colon carcinoma cells (CT-26) were used to set up a tumor-bearing mouse model. After 14 days of GCP treatment, the weights of tumors were significantly reduced. In addition, HE staining of tissue sections reflected that GCP could effectively inhibit tumor metastasis. 16SrRNA high-throughput sequencing of fecal samples showed a significant change between the model group and GCP group in the composition of gut microbiota. Subsequently, gut microbiota depletion and fecal transplantation experiments further confirmed the relationship between the anti-tumor effects of GCP and gut microbiota. Following depletion of gut microbiota, GCP cannot inhibit tumor growth. Fecal transplantation experiments found that transplanting the feces of GCP-treated mice, to a certain extent, could inhibit tumor growth and metastasis. These results indicate that Glycyrrhiza Polys...Continue Reading

Citations

Jul 30, 2020·The Biochemical Journal·Riddhi Trivedi, Kalyani Barve
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Shaobao ZhangZhiyong Xie
Jun 17, 2020·Frontiers in Pharmacology·Qing-Xia GanQin-Wan Huang
Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Tianqing SangHongguang Zhou
Oct 22, 2020·Mediators of Inflammation·Shichang BianWeisheng Wang
May 15, 2020·Seminars in Cancer Biology·Huifang SiXuhong Lin
Feb 25, 2021·The American Journal of Chinese Medicine·Xiao LiHaixue Kuang
Apr 23, 2021·International Journal of Biological Macromolecules·Zelalai SimayiNigary Yadikar
Apr 9, 2021·The American Journal of Chinese Medicine·Hui ZhaoHaibo Xu
Apr 16, 2021·The American Journal of Chinese Medicine·Qiao ZhangYuping Tang

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