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Inhibition Effects in the Hydrolysis Reactions of Esters and Peptides Catalyzed by Carboxypeptidase A: An Example of Cooperative Binding Effects with a Monomeric Enzyme

Bioorganic Chemistry

Aug 1, 2000

A Rahmo, Thomas H. Fife

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Abstract

N-benzoyl-L-phenylalanyl-L-phenylalanine is an excellent peptide substrate for carboxy-peptidase A; at 30 degrees C and pH 7.5, K(m) is 2.6 x 10(-5) M while k(cat) is 177 s(-1) (k(cat)/K(m) = 6.8 x 10(6) M(-1) s(-1)). Indole-3-acetic acid is a noncompetitive or mixed inhibitor towards t...read more

Mentioned in this Paper

Radiographic Imaging Procedure
Carboxyl Group
Phenylalanine
CNDP2 gene
Phenyllactate
Aminopeptidase
Binding (Molecular Function)
Plain X-ray
Penicillopepsin
Pentosuria
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Inhibition Effects in the Hydrolysis Reactions of Esters and Peptides Catalyzed by Carboxypeptidase A: An Example of Cooperative Binding Effects with a Monomeric Enzyme

Bioorganic Chemistry

Aug 1, 2000

A Rahmo, Thomas H. Fife

PMID: 11034784

DOI: 10.1006/bioo.2000.1161

Abstract

N-benzoyl-L-phenylalanyl-L-phenylalanine is an excellent peptide substrate for carboxy-peptidase A; at 30 degrees C and pH 7.5, K(m) is 2.6 x 10(-5) M while k(cat) is 177 s(-1) (k(cat)/K(m) = 6.8 x 10(6) M(-1) s(-1)). Indole-3-acetic acid is a noncompetitive or mixed inhibitor towards t...read more

Mentioned in this Paper

Radiographic Imaging Procedure
Carboxyl Group
Phenylalanine
CNDP2 gene
Phenyllactate

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Paper Details
References
  • References19
  • Citations
12
  • References19
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

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