Inhibition impairment in frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease: clinical assessment and metabolic correlates

Brain Imaging and Behavior
Jordi A Matías-GuiuJorge Matías-Guiu

Abstract

The ability to reject an automatic tendency, i.e. inhibition, has been linked to the prefrontal cortex, but its neural underpinnings are still controversial. Neurodegenerative diseases represent an interesting model to explore this issue, given its frequent impairment in these disorders. We investigated the inhibitory impairment and its neural basis using four different tests, which evaluate the presence of inhibitory dysfunction (Stroop test, Hayling test, and two graphical perseveration tests), and assessed their correlation with brain metabolism using 18F-fluorodeoxyglucose positron emission tomography in a group of 76 participants with behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and healthy controls (HC). Inhibition impairment was more frequent in bvFTD and AD, than ALS and HC. AD and bvFTD only differed in the strategy used in Hayling test, and the frequency of impairment in graphical perseveration tests. Correlation between inhibition tests was moderate. The Stroop test correlated with several regions of the frontal and parietal lobes, mainly on the left side. Hayling test correlated with almost all regions of the frontal lobe and, especially, with the ...Continue Reading

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Citations

Sep 24, 2019·Journal of the International Neuropsychological Society : JINS·Luciano I MarianoLeonardo C de Souza
Sep 10, 2019·Journal of Alzheimer's Disease : JAD·Gäetan ChanteloupJordi A Matías-Guiu
Feb 15, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Maxime MontembeaultUNKNOWN PrevDemAls study group
Oct 24, 2019·Journal of Alzheimer's Disease : JAD·Jordi A Matías-GuiuJavier J González-Rosa
Dec 3, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Alfonso Delgado-ÁlvarezJordi A Matias-Guiu
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Sep 28, 2021·Journal of the International Neuropsychological Society : JINS·Alfonso Delgado-ÁlvarezJordi A Matias-Guiu
Apr 25, 2020·Multiple Sclerosis and Related Disorders·Jordi A Matías-GuiuJordi Peña-Casanova

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Software Mentioned

Anatomic
SPSS Statistics
Marsbar
Statistical Parametric Mapping

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