PMID: 11342026May 9, 2001Paper

Inhibition kinetics of green crab (Scylla serrata) alkaline phosphatase by zinc ions: a new type of complexing inhibition

Biochimica Et Biophysica Acta
R Q ZhangH M Zhou

Abstract

The Tsou method was used to study the kinetic course of inactivation of green crab alkaline phosphatase by zinc ions. The results show that the enzyme was inactivated by a complexing scheme which has not been previously identified. The enzyme first reversibly and quickly binds Zn(2+) and then undergoes a slow reversible course to inactivation and slow conformational change. The inactivation reaction is a single molecule reaction and the apparent inactivation rate constant is for a saturated reaction being independent of Zn(2+) concentration if the concentration is sufficiently high. The microscopic rate constants of inactivation and the association constant were determined from the measurements.

References

Feb 22, 1977·Biochemistry·W F BosronB L Vallee
Jan 1, 1992·Annual Review of Biophysics and Biomolecular Structure·J E Coleman
Mar 20, 1991·Journal of Molecular Biology·E E Kim, H W Wyckoff
Jul 1, 1974·The Biochemical Journal·K Hiwada, E D Wachsmuth
Dec 1, 1968·Biochemistry·R T SimpsonG H Tait
Apr 27, 1995·Biochimica Et Biophysica Acta·L de La FournièreB Roux
May 1, 1994·Molecular Microbiology·J E Murphy, E R Kantrowitz
Nov 1, 1996·Biochemistry and Molecular Biology International·W Z XieH M Zhou
Sep 18, 1998·Biochemistry and Molecular Biology International·P Z YangH M Zhou
Sep 21, 2010·Blood·Shalini L ChudasamaGowthami M Arepally

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Citations

Nov 29, 2008·Extremophiles : Life Under Extreme Conditions·Hanan DahchePeter J Kennelly
Jun 27, 2002·Journal of Molecular Biology·Maaike de BackerEdward Hough
Jan 18, 2003·The International Journal of Biochemistry & Cell Biology·Fan WangHai-Meng Zhou
Mar 31, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Xiao-Lan XieQing-Xi Chen
Jul 4, 2006·International Journal of Biological Macromolecules·Jin-Jin XieXue-Min Yang
Sep 2, 2006·Chemical & Pharmaceutical Bulletin·Kyung-Hee ParkMyong-Joon Hahn
Jan 24, 2002·The Journal of Biological Chemistry·Claudette KleinAllyn C Howlett
Jul 14, 2012·Bioscience, Biotechnology, and Biochemistry·Yue-Xiu SiGuo-Ying Qian
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Ying-Xia ZhangHai-Meng Zhou
Nov 14, 2002·Biochimica Et Biophysica Acta·Wibke KallowHans von Döhren
Dec 3, 2010·Journal of Agricultural and Food Chemistry·Jiang-Xing ZhuangQing-Xi Chen
Jun 27, 2002·Journal of Agricultural and Food Chemistry·Qing-Xi Chen, Isao Kubo

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