Inhibition mechanisms of hematophagous invertebrate compounds acting on the host blood coagulation and platelet aggregation pathways

Biochimie
Junko UrataYuji Kaneko

Abstract

To facilitate blood feeding, hematophagous invertebrates have evolved a sophisticated array of physiological compounds that counteract homeostatic systems and inflammatory reactions of the vertebrate host. For this reason, hematophagous invertebrates possess a variety of anticoagulation components that are inhibitors of coagulant factors or antagonists of the platelet receptor. The examination of kinetic data and the crystal structure analysis have exposed the inhibition mechanisms for many of these anticoagulant reagents. Here, we attempt to classify the antihemostatic molecules and to focus on the kinetic approaches that have been instrumental in defining these mechanisms.

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Citations

Dec 2, 2010·Die Naturwissenschaften·Josué Martínez-de la PuenteJavier Martínez
Apr 25, 2013·Journal of Materials Science. Materials in Medicine·Wasinee BoonkongNuttha Thongchul
Dec 8, 2009·Medicinal Research Reviews·Yu-Kai Lee, Mark R Player
Jul 28, 2009·Insect Biochemistry and Molecular Biology·María Angeles Corral-RodríguezPablo Fuentes-Prior

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