Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice.

Diabetologia
S J Y WangJ R S Arch

Abstract

The 11beta-hydroxysteroid dehydrogenase type-1 inhibitor BVT.2733 lowers blood glucose and insulin in mutant mouse models of obesity and diabetes. Its effects on energy balance and body composition, and their contribution to improved glucose homeostasis have received little attention. BVT.2733 (100 mg/kg, orally) was given twice daily to lean and diet-induced obese mice for 16 or 17 days. A group of obese mice was pair-fed to the amounts consumed by BVT.2733-treated mice. In both obese and lean mice, BVT.2733 reduced food intake and weight gain, but increased water intake. Pair-feeding caused almost as great a decrease in body weight as BVT.2733. Energy expenditure was 38+/-8% higher in the BVT.2733-treated obese mice than in the pair-fed mice. Terminal plasma corticosterone was raised, lean body weight reduced and percentage fat unchanged in the pair-fed mice (control, 47.8+/-2.6%; pair-fed, 47.1+/-1.9%), whereas BVT.2733 did not reduce lean mass, but did reduce percentage fat (40.9+/-2.0%). BVT.2733 but not pair-feeding reduced both the glucose tolerance AUC and the plasma insulin concentration 30 min after giving glucose. BVT.2733 reduced food intake but prevented a concomitant reduction in lean body mass and energy expendit...Continue Reading

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Citations

Feb 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M BerthiaumeY Deshaies
Nov 9, 2011·Clinical and Experimental Pharmacology & Physiology·Nirav DhaneshaMukul Jain
Dec 26, 2012·Journal of Molecular Endocrinology·Hanze DuYanjun Liu
Sep 29, 2009·Expert Opinion on Therapeutic Patents·Alex Odermatt
Mar 28, 2008·Expert Opinion on Investigational Drugs·Katherine A HughesBrian R Walker
Jun 2, 2012·Metabolism: Clinical and Experimental·Panagiotis AnagnostisDimitri P Mikhailidis
Jul 3, 2010·Trends in Endocrinology and Metabolism : TEM·Erika Harno, Anne White
Nov 1, 2008·Molecular and Cellular Endocrinology·Karen E ChapmanJonathan R Seckl
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Mar 16, 2016·Translational Psychiatry·P P SannaV Repunte-Canonigo
Aug 4, 2018·International Journal of Molecular Sciences·Eline N KuipersMariëtte R Boon
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Magalie BerthiaumeYves Deshaies
Mar 11, 2020·Frontiers in Endocrinology·Elina AkalestouGuy A Rutter
Oct 27, 2007·Neurochemical Research·Karen E Chapman, Jonathan R Seckl
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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