PMID: 2511250Dec 1, 1989Paper

Inhibition of 125I-epidermal growth factor binding to cultured keratinocytes by antiproliferative molecules gamma interferon, cyclosporin A, and transforming growth factor-beta

The Journal of Investigative Dermatology
B J Nickoloff, R S Mitra

Abstract

The growth of cultured human keratinocytes (KC) is inhibited by gamma interferon (IFN-gamma), cyclosporin A and transforming growth factor-beta, but not by tumor necrosis factor. When these antiproliferative molecules were added to KC they induced a concentration and time-dependent inhibition of 125I-epidermal growth factor (I-EGF) binding. These anti-proliferative molecules primarily reduced the number of binding sites by approximately 25%-50% without affecting the binding affinity. Tumor necrosis factor did not influence the ligand binding by I-EGF. In parallel with the ability of the antiproliferative molecules to inhibit I-EGF binding, there was an increase in transforming growth factor-alpha production. These results suggest that several different antiproliferative molecules may share a common mechanism to inhibit cell growth by reducing I-EGF binding to KC.

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L BeguinotI Pastan
Mar 1, 1986·The Journal of Investigative Dermatology·L B NanneyL E King
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K C ZoonH Arnheiter
Mar 1, 1987·The Journal of Cell Biology·R FrieselT Maciag
Sep 1, 1983·The Journal of Investigative Dermatology·E J O'Keefe, R E Payne

❮ Previous
Next ❯

Citations

Apr 1, 1991·European Journal of Haematology·H Jernberg-WiklundK Nilsson
May 1, 1996·Journal of Cellular Physiology·A J WuB J Baum
Nov 1, 1990·The British Journal of Dermatology·B J Nickoloff, R S Mitra
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·M Piontek, R Porschen
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G Suchett-KayeO Barsotti
Feb 1, 1994·Experimental Dermatology·L KeményT Ruzicka
Mar 1, 1995·Clinics in Dermatology·F Van RuissenJ Schalkwijk
Oct 9, 1998·The Journal of Investigative Dermatology·M BoukhelifaF Braut-Boucher
Aug 15, 2002·Nitric Oxide : Biology and Chemistry·Ann SchwentkerTimothy R Billiar
Oct 19, 2004·Journal of Dermatological Science·Yuji ShirakataKoji Hashimoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.