Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation.

Molecular Medicine Reports
Chang DengHua Jin

Abstract

Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is a potential candidate for PD treatment, there have been no reports on the effects of SF on ER stress in PD. In this study, we investigated the cytoprotective effects of SF on 6-hydroxydopamine (6-OHDA)-induced ER stress in rat PC12 cells. Pre-treatment with SF elicited cytoprotection against 6-OHDA-induced cytotoxicity. Consistent with its cytoprotective action, SF significantly inhibited subsequent ER stress, including the expression of Bip and the C/EBP homologous protein. We also found that transfection with NF-E2-related factor-2 (Nrf2) siRNA reversed the inhibitory effects of SF on 6-OHDA-induced ER stress responses. In conclusion, our results show that SF can prevent ER stress response induced by 6-OHDA through the activation of Nrf2. SF may be a therapeutic candidate for the treatment of ER...Continue Reading

Citations

Sep 13, 2018·Current Medicinal Chemistry·Alessandro Venditti, Armandodoriano Bianco
Nov 20, 2020·International Journal of Molecular Sciences·Giovanni SchepiciEmanuela Mazzon
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sajad FakhriEduardo Sobarzo-Sánchez
Mar 4, 2021·Biomolecules·Talya ShachamGerardo Z Lederkremer
Jun 26, 2021·Frontiers in Aging Neuroscience·Haigang RenGuanghui Wang

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