Inhibition of a Cl-/HCO3(-)ATPase in the avian salt gland by furosemide and ethacrynic acid

Cell Biology International Reports
D Gassner, H Komnick

Abstract

An ouabain-insensitive, Mg2+-dependent, chloride- and bicarbonate-stimulated ATPase is present in salt gland homogenates of domestic ducks (Anas platyrhynchos). Furosemide and ethacrynic acid are non-competitive inhibitors of this enzyme in vitro. The inhibitor constant of furosemide is Ki = 2.5 mM and of ethacrynic acid Ki = 1.9 mM. In contrast, under the same conditions the salt gland Na+/K+-ATPase activity is not inhibited by furosemide, whereas ethacrynic acid becomes inhibitory only at higher concentrations (10 mM).

Citations

Oct 17, 2014·The Journal of Membrane Biology·S DzneladzeG Chkadua
Mar 9, 2012·The Journal of Membrane Biology·Sopio DzneladzeZurab Kometiani
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·D Gassner, H Komnick
May 15, 1985·Biochemical Pharmacology·C InagakiJ Ishiko

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