PMID: 8589450Nov 1, 1995Paper

Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase

Molecular Biology of the Cell
J ThorburnA Thorburn

Abstract

Signaling via the Ras pathway involves sequential activation of Ras, Raf-1, mitogen-activated protein kinase kinase (MKK), and the extracellular signal-regulated (ERK) group of mitogen-activated protein (MAP) kinases. Expression from the c-Fos, atrial natriuretic factor (ANF), and myosin light chain-2 (MLC-2) promoters during phenylephrine-induced cardiac muscle cell hypertrophy requires activation of this pathway. Furthermore, constitutively active Ras or Raf-1 can mimic the action of phenylephrine in inducing expression from these promoters. In this study, we tested whether constitutively active MKK, the molecule immediately downstream of Raf, was sufficient to induce expression. Expression of constitutively active MKK induce ERK2 kinase activity and caused expression from the c-Fos promoter, but did not significantly activate expression of reporter genes under the control of either the ANF or MLC-2 promoters. Expression of CL100, a phosphatase that inactivates ERKs, prevented expression from all of the promoters. Taken together, these data suggest that ERK activation is required for expression from the Fos, ANF, and MLC-2 promoters but MKK and ERK activation is sufficient for expression only from the Fos promoter. Constituti...Continue Reading

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Citations

Aug 11, 2004·International Journal of Cardiology·Ruri OhkiKazuyuki Shimada
Apr 6, 2000·The American Journal of Cardiology·A Clerk, P H Sugden
Apr 6, 1999·Trends in Cardiovascular Medicine·G W Dorn, J H Brown
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R L NicolE N Olson
Feb 22, 2001·Annual Review of Physiology·J D Molkentin, G W Dorn
Feb 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Yi JinLeif D Nelin
Apr 21, 2007·The Journal of Clinical Investigation·Antoine MuchirHoward J Worman
Oct 14, 1998·The Journal of Clinical Investigation·G ChoukrounT Force
Mar 20, 2009·Molecular Medicine·Anastasia StavropoulouMichael Koutsilieris
Jul 30, 2000·Journal of Molecular and Cellular Cardiology·G J BabuM Periasamy
Mar 16, 2000·International Journal of Experimental Pathology·K Yamauchi-Takihara, T Kishimoto
Aug 14, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Aida SalamehIngo Daehnert
Oct 11, 2008·Journal of Molecular and Cellular Cardiology·Jeffery D Molkentin, Jeffrey Robbins
Jul 25, 2014·Biology of the Cell·Monica CarmosinoMaria Svelto
Aug 18, 2004·Biochemical and Biophysical Research Communications·Doubun HayashiIssei Komuro
Sep 27, 2003·Biochemical and Biophysical Research Communications·Mohammad Saifur RohmanMasafumi Matsuo
Apr 17, 2016·International Journal of Cardiology·Zuoguang WangYongxiang Wei
May 20, 1998·Biochemical and Biophysical Research Communications·P H WangJ J Bahl
Oct 29, 1998·Biochemical and Biophysical Research Communications·M B AnderssonM A Bogoyevitch
Mar 19, 2014·Journal of Molecular and Cellular Cardiology·Anne C KöhlerLars S Maier
Feb 7, 1998·Hypertension·T Force, J V Bonventre
Nov 2, 2002·Circulation Research·Orlando F Bueno, Jeffery D Molkentin
Apr 3, 1999·Circulation Research·E N Olson, J D Molkentin
Apr 3, 1999·Circulation Research·P H Sugden
May 15, 2002·Endocrine Journal·Yunzeng ZouIssei Komuro
Jan 29, 2008·Experimental Biology and Medicine·Xiao-Jing ZouShang-Long Yao

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