Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.

Bioorganic & Medicinal Chemistry Letters
Heidi R BokeschTawnya C McKee

Abstract

Five new naphthopyrones (1-5) along with the known compounds TMC-256A1, 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one, TMC-256C1, comaparvin, 6-methoxycomaparvin, and 6-methoxycomaparvin 5-methyl ether (6-11) were isolated from crinoids of the family Comasteridae. All compounds were tested for their ability to inhibit the multidrug transporter ABCG2, which plays a role in drug resistance. Six of the seven angular naphthopyrones showed moderate activity with <60% inhibition of ABCG2-mediated transport as compared to the positive control fumitremorgin C. None of the linear naphthopyrones inhibited ABCG2-mediated efflux.

References

Oct 19, 2000·Journal of the National Cancer Institute·J W JonkerA H Schinkel
Jun 27, 2009·ACS Chemical Biology·Curtis J HenrichKirk R Gustafson

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Citations

Apr 10, 2015·Marine Drugs·Lilia CherigoSergio Martinez-Luis
Sep 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Chai ChenZhi-Hong Wen
Dec 19, 2014·Applied Microbiology and Biotechnology·Elodie ChoqueFlorence Mathieu
Dec 23, 2016·Medicinal Research Reviews·Diana Peña-SolórzanoCristian Ochoa-Puentes
Mar 31, 2017·Natural Product Reports·Yunjiang FengRohan A Davis
Aug 24, 2018·Chemical & Pharmaceutical Bulletin·Le Thi VienChau Van Minh
May 1, 2014·Molecular Informatics·Floriane Montanari, Gerhard F Ecker
Nov 2, 2020·Developmental and Comparative Immunology·Ming Guo, Chenghua Li
Jun 2, 2020·Journal of Natural Products·Kah Yean LumRohan A Davis

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