Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

Journal of Affective Disorders
Yun WangXiaoxing Yin

Abstract

Numerous studies indicate that inflammation plays important roles in the development of depression. Astrocytes are crucial regulators of immune response in the central nervous system, and strongly activated by pro-inflammatory cytokines. We hypothesized that inhibition of activated astrocytes contributed to ameliorate depressive-like symptoms. This study evaluated the antidepressant-like effect of inhibition of activated astrocytes, by a well-established astrocyte inactivator fluorocitrate (FC), on a lipopolysaccharide (LPS)-induced model of depression. Forced swim test (FST), tail suspension test (TST) and sucrose preference test were used to assess depressive-like behaviors. The expression of fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and neuroinflammation were determined in the hippocampus and cortex. The results demonstrated that LPS increased immobility time in the TST and FST, reduced sucrose preference as well. LPS also enhanced the expression of IL-1β, TNF-α, iNOS and GFAP, accompanying with decreased expression of BDNF in the hippocampus and cortex. Inhibition of activated astrocytes by FC significantly prevented LPS- induced alteration in the FST, TST and sucrose preference test. Moreov...Continue Reading

Citations

Feb 6, 2020·Oxidative Medicine and Cellular Longevity·Perla Ugalde-MuñizAnahí Chavarría
Jul 24, 2020·Molecular Neurobiology·Leszek Rudzki, Michael Maes
Sep 26, 2020·Frontiers in Immunology·Linglin YangAnwen Shao
May 22, 2021·Journal of Neuroendocrinology·Savani Anbalagan
May 25, 2021·Frontiers in Psychiatry·Tao YanLinglin Yang
Jul 21, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N P Komysheva, G T Shishkina
Nov 24, 2021·Frontiers of Medicine·Yang LiaoZengqiang Yuan

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