PMID: 8610180Apr 2, 1996Paper

Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver

Proceedings of the National Academy of Sciences of the United States of America
T R KollmannH Goldstein

Abstract

To improve the usefulness of in vivo mode for the investigation of the pathophysiology of human immunodeficiency virus (HIV) infection, we modified the construction of SCID mice implanted with human fetal thymus and liver (thy/liv-SCID-hu mice) so that the peripheral blood of the mice contained significant numbers of human monocytes and T cells. After inoculation with HIV-1(59), a primary patient isolate capable of infecting monocytes and T cells, the modified thy/liv-SCID-hu mice developed disseminated HIV infection that was associated with plasma viremia. The development of plasma viremia and HIV infection in thy/liv-SCID-hu mice inoculated with HIV-1(59) was inhibited by acute treatment with human interleukin (IL) 10 but not with human IL-12. The human peripheral blood mononuclear cells in these modified thy/liv-SCID-hu mice were responsive to in vivo treatment with exogenous cytokines. Human interferon gamma expression in the circulating human peripheral blood mononuclear cells was induced by treatment with IL-12 and inhibited by treatment with IL-10. Thus, these modified thy/liv-SCID-hu mice should prove to be a valuable in vivo model for examining the role of immunomodulatory therapy in modifying HIV infection. Furthermor...Continue Reading

References

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Citations

Jun 1, 2006·Journal of Urban Health : Bulletin of the New York Academy of Medicine·M MarmorM Vogler
Feb 22, 2003·Experimental Parasitology·Laura Rivero-NavaJesús Calderón
Oct 12, 2001·Immunology Letters·M CarringtonS J O'Brien
Dec 2, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M F RabbiK A Roebuck
Jan 7, 1998·Immunological Reviews·O J CohenA S Fauci
Apr 5, 2014·PLoS Pathogens·Gustavo ValbuenaBarry Rockx
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·H D ShinM W Smith
Apr 19, 2008·Journal of Cellular and Molecular Medicine·Baojun ZhangYong Zhao
May 15, 2013·Microbiology and Immunology·Subha DamodharanRamakrishnan Usha
Oct 19, 2004·Molecular Immunology·Massimo Alfano, Guido Poli
Jan 28, 1999·Journal of the American Academy of Dermatology·J Breuer-McHamM Duvic
Jan 8, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·P SelvarajG Narendran
Feb 14, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Milena NasiMarcello Pinti
Oct 6, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vanessa A EvansSharon R Lewin
Nov 28, 2000·Annual Review of Genetics·S J O'BrienM W Smith
Mar 19, 2004·Revista do Hospital das Clínicas·Patrícia El BeituneErnesto Antônio Figueiró-Filho
Jun 5, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D S S RodriguesR Salomao
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·C Casper, E M Fenyö
Mar 9, 2012·Expert Review of Anti-infective Therapy·Tobias BoettlerMatthias von Herrath
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Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrina GeeAshok Kumar

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