PMID: 4240009Jul 1, 1969Paper

Inhibition of adenosine triphosphatase in sheep red cell membranes by oxidized glutathione

The Journal of General Physiology
D A DickD C Tosteson

Abstract

This paper reports inhibition of Na(+) + K(+)-stimulated, ouabain-inhibited adenosine triphosphatase (S-ATPase) in sheep red cell membranes by oxidized glutathione (GSSG). The results are consistent with the hypothesis that this inhibition depends upon the formation of a mixed disulfide between glutathione and -SH group(s) in the enzyme protein. Thus, inhibition of S-ATPase by GSSG proceeds more rapidly at alkaline than at neutral pH and is reversed by the addition of an excess of a compound containing reduced -SH groups (e.g. dithiothreitol). ATP protects S-ATPase against inhibition by GSSG and this protection depends on both the monovalent and divalent cation composition of the medium. Protection by ATP is more complete in the presence of K(+) than in the presence of Na(+).

References

Nov 22, 1965·Biochimica Et Biophysica Acta·J C Skou, C Hilberg
Jul 14, 1966·Annals of the New York Academy of Sciences·D C Tosteson
Apr 1, 1962·The Journal of Clinical Investigation·H S JACOB, J H JANDL
Jul 1, 1962·The Journal of Clinical Investigation·H S JACOB, J H JANDL

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Citations

Jul 1, 1972·Die Naturwissenschaften·C WaldS Dikstein
Jan 1, 1980·General Pharmacology·A PuppiP Práger
Jan 1, 1978·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·A Puppi, V N Kazachenko
Nov 1, 1973·Psychological Medicine·G J NaylorS F Whyte
Aug 1, 1971·Biological Reviews of the Cambridge Philosophical Society·E M Tucker
Jun 1, 1977·Journal of Neurochemistry·J E HeskethH W Reading
Jan 1, 1974·Annals of the New York Academy of Sciences·P K Lauf
Jul 1, 1975·Experimental Eye Research·D R Whikehart
May 15, 2003·International Journal of Toxicology·Güzide YücebilgiçSeyhan Tükel
May 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·G J NaylorN I Ward
Feb 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·G J NaylorE G Dick
Jun 1, 1973·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Werner A Müller, Gisela Buchal
Jan 1, 1973·European Journal of Clinical Investigation·P AreseG P Pescarmona
Jan 1, 1975·Animal Blood Groups and Biochemical Genetics·P G Board

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