PMID: 2105420Jan 1, 1990Paper

Inhibition of adenylate cyclase activity by polyamines in human erythrocyte plasma membranes

Life Sciences
N A KhanP Moulinoux

Abstract

Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutamine and lysine) did not influence the basal enzyme activity. Other cations (polylysine, polyarginine and polyglutamine) also did not affect the enzyme activity. Addition of all the three polyamines (Spd, Spm and Put) in the reaction mixture exhibited moderate inhibitory effect on the adenylate cyclase activity whether it was basal or activated with sodium fluoride or with forskolin. Since the three polyamines exhibited maximum inhibitory effect at 10 microM concentration which is within physiological limit for mammalian tissues, we suggest that there may be a regulatory function of these molecules on adenylate cyclase activity in human erythrocytes.

References

Jun 15, 1975·Experientia·G V ShahS S Rao
Sep 15, 1979·The Biochemical Journal·C ClôU Bachrach
Jan 26, 1976·Biochemical and Biophysical Research Communications·V J AtmarG D Kuehn
May 15, 1989·The Biochemical Journal·F Schuber
Sep 1, 1988·Journal of Molecular and Cellular Cardiology·C C Fan, H Koenig
Jan 1, 1988·Life Sciences·G MezzettiM S Moruzzi
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell
Sep 21, 1984·Science·M Schramm, Z Selinger
Jun 1, 1983·Molecular and Cellular Endocrinology·C Cochet, E M Chambaz
Oct 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M OtaV B Grossie
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M SchindlerM P Sheetz

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Citations

Nov 11, 2010·The Journal of Membrane Biology·Yuliya V Kucherenko, Florian Lang
May 16, 1990·European Journal of Pharmacology·C R MantioneE D London
May 1, 1991·Molecular and Cellular Endocrinology·G Scalabrino, E C Lorenzini
Mar 12, 1991·International Journal of Cancer. Journal International Du Cancer·M TatsutaH Taniguchi

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