Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles

Inflammopharmacology
Adel A GomaaNahla I Al-Zokeim

Abstract

The role of proinflammatory cytokines in adiposity is well established. The anti-inflammatory and antihyperglycemia effects of Boswellia serrata (B. Serrata) gum have been demonstrated by many investigators. The present study aimed to investigate the anti-obesity potential of B. serrata extract. The effects of B. serrata extract on lipase activity and acute food intake were investigated. The present study aimed to investigate the anti-obesity potential of B. serrata extract. The effects on lipase activity and acute food intake were investigated. Body weight changes, biochemical and histopathological markers were demonstrated in rats fed a high-fat diet. Boswellia serrata extract inhibited alterations in pancreatic lipase activity, but orlistat was more efficacious. B. serrata and ephidrene, but not orlistat, significantly suppressed cumulative food intake in mice. In obese rats, B. serrata or orlistat significantly decreased weight gain and weight of visceral white adipose tissue. B. serrata-treated animals exhibited a significant reduction in serum glucose, TC, TG, LDL-C, FFA, IL-1β, TNF-α, insulin and leptin levels of obese rat groups while HDL-C and adiponectin levels were significantly increased by orlistat or B. serrata ex...Continue Reading

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Citations

Oct 28, 2019·Reviews in Endocrine & Metabolic Disorders·Syeda Momna IshtiaqJunaid Ali Khan
Jul 14, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H P T Ammon
Jan 22, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liliya V VasilevaMilen I Georgiev

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
GraphPad Prism

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