Inhibition of adult emergence of Aedes aegypti in simulated domestic water-storage containers by using a controlled-release formulation of pyriproxyfen

Journal of the American Mosquito Control Association
Chang Moh SengMichael B Nathan

Abstract

Concrete domestic water-storage jars are a common larval habitat of the dengue vector Aedes aegypti in countries of Southeast Asia. The efficacy of a novel controlled-release formulation of the insect growth regulator pyriproxyfen, designed to inhibit adult emergence for 6 months (the approximate duration of the main dengue transmission season in many endemic countries) was tested in Cambodia against a local strain of Ae. aegypti in 200-liter jars. The resin-based formulation contained 4.8% active ingredient (AI). At target dosages of 18, 27, and 36 ppb of AI, inhibition of adult emergence remained above 95% for at least 2 months. After 3 months at 18 ppb AI, the residual efficacy was significantly lower than for the higher dosages (P < 0.05). At the higher dosages, inhibition of adult emergence was > or = 87% for 6 months. At a dosage of 27 ppb AI, monthly removal and replacement of two thirds of the water did not reduce efficacy (P > 0.05). Potential operational advantages and challenges of using the formulation are discussed. Larger-scale efficacy studies are recommended in community settings.

Citations

Jun 9, 2007·Malaria Journal·Silas MajambereUlrike Fillinger
Jun 12, 2012·Journal of Medical Entomology·Christopher J Geden, Gregor J Devine
Apr 15, 2015·Pesticide Biochemistry and Physiology·Rizwan Mustafa ShahNaeem Abbas
Mar 17, 2009·Cadernos de saúde pública·Eng-Eong Ooi, Duane J Gubler
Nov 7, 2019·Tropical Medicine & International Health : TM & IH·Melania Teresita JungesAníbal Eduardo Carbajo
Jun 13, 2020·PLoS Neglected Tropical Diseases·John Christian HustedtNeal Alexander
Apr 27, 2012·Journal of the American Mosquito Control Association·Garry WebbBryce Peters

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