Inhibition of aflatoxin biosynthesis by tolnaftate.

Applied and Environmental Microbiology
S N KhanT A Venkitasubramanian

Abstract

Tolnaftate [2-napthyl-N-methyl-N-(m-tolyl)thionocarbamate], an antifungal drug, is widely used to control superficial fungal infections in humans and other animals. In this study the effect of tolnaftate on aflatoxin biosynthesis by Aspergillus parasiticus NRRL 3240 was investigated. Tolnaftate changed the morphology of A. parasiticus to yeastlike forms and inhibited aflatoxin formation. The formation of aflatoxin G was blocked considerably, indicating a metabolic block in the conversion of aflatoxin B to aflatoxin G. The incorporation of [1-14C]acetate into aflatoxin was significantly inhibited at a concentration of 1 mM tolnaftate. The presence of zinc in the resuspension buffer resulted in reversal of the tolnaftate-induced inhibition of aflatoxin G1 biosynthesis.

References

Dec 1, 1977·Bacteriological Reviews·K K MaggonT A Venkitasubramanian
Jan 1, 1977·Annual Review of Microbiology·G S Kobayashi, G Medoff
Jan 27, 1975·Annals of the New York Academy of Sciences·G A Bean, G W Rambo
Sep 1, 1976·Applied and Environmental Microbiology·S K GuptaT A Venkitasubramanian
Dec 1, 1976·Applied and Environmental Microbiology·S K GuptaT A Venkitasubramanian
Jun 1, 1975·Applied Microbiology·S K Gupta, T A Venkitasubramanian
Dec 1, 1975·Journal of General Microbiology·S R GuptaT A Venkitasubramanian
Oct 31, 1975·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·S K Gupta, T A Venkitasubramanian
May 1, 1973·Journal of Agricultural and Food Chemistry·D P Hsieh
Oct 15, 1973·Experientia·K K Maggon, T A Venkitasubramanian
Sep 1, 1971·Applied Microbiology·T V ReddyT A Venkitasubramanian
Oct 1, 1970·Canadian Journal of Microbiology·R W Detroy, C W Hesseltine
Mar 1, 1971·Journal of General Microbiology·R W Detroy, A Ciegler
May 11, 1964·Biochimica Et Biophysica Acta·J ADYE, R I MATELES

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.