Inhibition of allergen-mediated histamine release from human cells by ketotifen and oxatomide. Comparison with other H1 antihistamines

Respiration; International Review of Thoracic Diseases
M Radermecker

Abstract

We have studied the ability of four H1 antihistamines, ketotifen, oxatomide, clemastine and promethazine, and of disodium cromoglycate (DSCG) to inhibit in vitro histamine release mediated by antigen from passively sensitized human lung and from basophilic leukocytes. Anaphylactic histamine release from human leukocytes is inhibited in a comparable fashion by oxatomide, clemastine and promethazine at concentrations just below those inducing histamine release in the absence of antigen. Ketotifen causes a significantly weaker inhibition without inducing histamine release and DSCG is not at all active in this model. On human lung, oxatomide, clemastine and promethazine give a strong and similar inhibition which is linearly related to the dose. Ketotifen markedly differs in this respect, inhibiting according to a bell-shaped dose-response curve and at concentrations closely comparable to that of DSCG. Thus, we confirm that H1 blockers, such as clemastine and promethazine, inhibit anaphylactic histamine release from basophils and human lung but only at high concentrations which may be cytotoxic. Oxatomide behaves very much like these antihistamines. Ketotifen, on the other hand, gives in both models a different pattern of inhibition...Continue Reading

Citations

May 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·I S GushchinA A Serov
Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G Zwadlo-KlarwasserW Schmutzler
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Dec 11, 1991·International Journal of Dermatology·G C FrancosJ F Burke
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Mar 23, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guo-Du WangJackie D Wood

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