Inhibition of allergic airway responses by inhaled low-molecular-weight heparins: molecular-weight dependence

Journal of Applied Physiology
J Martinez-SalasT Ahmed

Abstract

Inhaled heparin prevents antigen-induced bronchoconstriction and inhibits anti-immunoglobulin E-mediated mast cell degranulation. We hypothesized that the antiallergic action of heparin may be molecular weight dependent. Therefore, we studied the effects of three different low-molecular-weight fractions of heparin [medium-, low-, and ultralow-molecular-weight heparin (MMWH, LMWH, ULMWH, respectively)] on the antigen-induced acute bronchoconstrictor response (ABR) and airway hyperresponsiveness (AHR) in allergic sheep. Specific lung resistance was measured in 22 sheep before and after airway challenge with Ascaris suum antigen, without and after pretreatment with inhaled fractionated heparins at doses of 0.31-5.0 mg/kg. Airway responsiveness was estimated before and 2 h postantigen as the cumulative provocating dose of carbachol in breath units that increased specific lung resistance by 400%. All fractionated heparins caused a dose-dependent inhibition of ABR and AHR. ULMWH was the most effective fraction, with the inhibitory dose causing 50% protection (ID50) against ABR of 0.5 mg/kg, whereas ID50 values of LMWH and MMWH were 1.25 and 1.8 mg/kg, respectively. ULMWH was also the most effective fraction in attenuating AHR; the ID...Continue Reading

References

Nov 1, 1978·The Biochemical Journal·T C LaurentU Lindahl
Mar 1, 1992·The American Review of Respiratory Disease·T AhmedJ D'Brot
Dec 1, 1985·Journal of Cellular Physiology·T C WrightM J Karnovsky
Jul 1, 1985·Journal of Cellular Physiology·J J CastellotM J Karnovsky
Jan 1, 1993·The American Review of Respiratory Disease·S D BowlerP S Lavercombe
Jul 8, 1993·The New England Journal of Medicine·T AhmedI Danta
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·J GarrigoT Ahmed
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·Z DiamantP J Sterk
Jun 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J HarenbergD L Heene
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·T AhmedB Sanpedro

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Citations

Jun 19, 2003·British Journal of Pharmacology·Rachel A BrownClive P Page
Apr 19, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ayca Yildiz-Pekoz, Yildiz Ozsoy
Apr 9, 2015·American Journal of Therapeutics·Berna Solak
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·T AhmedI Danta
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D D S Collie
Nov 24, 2011·Macromolecular Bioscience·Felipe A Oyarzun-AmpueroDolores Torres
Jan 5, 2002·European Journal of Pharmacology·Tomoyuki YahataMitsuhiro Yokoyama
Feb 13, 2001·Pulmonary Pharmacology & Therapeutics·Y S HwangJ R Snapper
Jul 25, 2017·Carbohydrate Polymers·Bahtiyor MuhitdinovAbbaskhan Turaev
Sep 14, 2000·Medical Hypotheses·A L Russell, M F McCarty
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Dewan ZengRiccardo Polosa
Jan 22, 2005·European Journal of Pharmacology·Jana SuchankovaEsteban J Morcillo

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