PMID: 2118501Sep 1, 1990Paper

Inhibition of ammonia monooxygenase in Nitrosomonas europaea by carbon disulfide

Journal of Bacteriology
M R HymanD J Arp

Abstract

Carbon disulfide has long been recognized as a potent inhibitor of nitrification, and it is the likely active component in several nitrification inhibitors suitable for field use. The effects of this compound on Nitrosomonas europaea have been investigated, and the site of action has been determined. Low concentrations of CS2 (less than 400 microM) produced a time-dependent inhibition of ammonia-dependent O2 uptake but did not inhibit hydrazine-oxidizing activity. CS2 also produced distinct changes in difference spectra of whole cells. These results suggest that ammonia monooxygenase (AMO) is the site of action of CS2. Unlike the case for thiourea and acetylene, saturating concentrations of CS2 did not fully inhibit AMO, and the inhibition resulted in a low but significant rate of ammonia-dependent O2 uptake. The effects of CS2 were not competitive with respect to ammonia concentration, and the inhibition by CS2 did not require the turnover of AMO to take effect. The ability of CS2-treated cells to incorporate [14C]acetylene into the 28-kilodalton polypeptide of AMO was used to demonstrate that the effects of CS2 are compatible with a mode of action which involves a reduction of the rate of turnover of AMO without effects on th...Continue Reading

References

Jul 1, 1977·Acta Pharmacologica Et Toxicologica·H SavolainenH Vainio
Mar 1, 1985·The Biochemical Journal·J H Shears, P M Wood
May 1, 1985·The Biochemical Journal·M R Hyman, P M Wood
Aug 1, 1973·Journal of Bacteriology·A B Hooper, K R Terry
Apr 15, 1983·The Biochemical Journal·M R Hyman, P M Wood
Dec 1, 1988·Applied and Environmental Microbiology·M R HymanD J Arp

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Citations

Oct 11, 2016·Chemical Society Reviews·Anthony W DeMartinoPeter C Ford
Feb 23, 2020·Applied and Environmental Microbiology·Chloë L WrightLaura E Lehtovirta-Morley
Mar 13, 2015·FEMS Microbiology Ecology·Anne DaebelerHendrikus J Laanbroek
Oct 6, 1998·Applied and Environmental Microbiology·L Y Stein, D J Arp
Dec 25, 2008·Applied Microbiology and Biotechnology·Yinghao YuBruce A Ramsay
Jan 30, 2021·Chemistry : a European Journal·Christian SchneiderC Gunnar Werncke
Apr 1, 1993·Journal of Bacteriology·S A EnsignD J Arp
Nov 1, 1993·Applied and Environmental Microbiology·L Y JulietteD J Arp
Nov 16, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Abhishek MandalAnupama Singh

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