Inhibition of AMP deaminase as therapeutic target in cardiovascular pathology

Pharmacological Reports : PR
Magdalena A ZabielskaR T Smolenski

Abstract

AMP deaminase (AMPD; EC 3.5.4.6) catalyzes hydrolysis of the amino group from the adenine ring of AMP resulting in production of inosine 5'-monophosphate (IMP) and ammonia. This reaction helps to maintain healthy cellular energetics by removing excess AMP that accumulates in energy depleted cells. Furthermore, AMPD permits the synthesis of guanine nucleotides from the larger adenylate pool. This enzyme competes with cytosolic 5'-nucleotidases (c5NT) for AMP. Adenosine, a product of c5NT is a vasodilator, antagonizes inotropic effects of catecholamines and exerts anti-platelet, anti-inflammatory and immunosuppressive activities. The ratio of AMPD/c5NT defines the amount of adenosine produced in adenine nucleotide catabolic pathway. Inhibition of AMPD could alter this ratio resulting in increased adenosine production. Besides the potential effect on adenosine production, elevation of AMP due to inhibition of AMPD could also lead to activation of AMP regulated protein kinase (AMPK) with myriad of downstream events including enhanced energetic metabolism, mitochondrial biogenesis and cytoprotection. While the benefits of these processes are well appreciated in cells such as skeletal or cardiac myocytes its role in protection of end...Continue Reading

References

Dec 28, 1978·Pflügers Archiv : European journal of physiology·J SchraderE Gerlach
Jun 15, 1978·European Journal of Biochemistry·N OgasawaraT Watanabe
Jan 1, 1992·Neurology·R L SabinaE W Holmes
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T MorisakiE W Holmes
May 1, 1990·International Journal of Sports Medicine·J M Lowenstein
May 1, 1989·Molecular and Cellular Biology·R L SabinaE W Holmes
Jan 1, 1985·Annual Review of Physiology·R B Jennings, C Steenbergen
Jan 1, 1989·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C Des RosiersE Gerlach
Sep 1, 1985·Basic Research in Cardiology·S NeesE Gerlach
Jun 1, 1986·Pflügers Archiv : European journal of physiology·A DeussenJ Schrader
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R MarquetantE W Holmes
Apr 1, 1972·Physiological Reviews·J M Lowenstein
Jan 1, 1984·The International Journal of Biochemistry·N OgasawaraT Watanabe
Feb 2, 1982·Biochimica Et Biophysica Acta·N OgasawaraT Asano
Nov 1, 1994·Journal of Molecular and Cellular Cardiology·Z KochanA L Seymour
Sep 1, 1993·Molecular and Cellular Biology·T Morisaki, E W Holmes
Apr 15, 1993·The Biochemical Journal·J K ThakkarH M Sharif
Apr 21, 1993·Biochimica Et Biophysica Acta·W N FishbeinE W Holmes
May 1, 1993·The Journal of Clinical Investigation·H MorisakiE W Holmes
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Sep 18, 1997·The Biochemical Journal·D K Mahnke-ZizelmanR L Sabina
Oct 7, 1998·Journal of Applied Physiology·B NormanR L Sabina
Oct 12, 2000·Journal of the American College of Cardiology·J L AndersonN Hart
Feb 15, 2001·Journal of Medicinal Chemistry·S R KasibhatlaM D Erion
Dec 31, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F CarlucciE Marinello

❮ Previous
Next ❯

Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
May 19, 2018·The FEBS Journal·Marcella CamiciMaria Grazia Tozzi
Jul 17, 2018·Journal of Cellular Biochemistry·Reza KhayamiSeyed Mahdi Hassanian
Dec 28, 2018·Nucleosides, Nucleotides & Nucleic Acids·Marta ToczekRyszard T Smolenski
Dec 28, 2018·Nucleosides, Nucleotides & Nucleic Acids·Barbara Kutryb-ZajacRyszard T Smolenski
Jan 21, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mario SubiabreLuis Sobrevia
Nov 23, 2016·Molecular Aspects of Medicine·Luis SilvaLuis Sobrevia
Jul 3, 2021·International Journal of Molecular Sciences·Marta TomczykRyszard T Smolenski
Oct 1, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marianna LovásziGyörgy Haskó

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.