PMID: 7535861Feb 15, 1995Paper

Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases

Journal of the National Cancer Institute
G TarabolettiR Giavazzi

Abstract

The importance of matrix metalloproteinases in angiogenesis, tumor growth, and metastasis is well known. However, little is known about the role of matrix metalloproteinases in the formation of hemangiomas and about the possible therapeutic use of matrix metalloproteinase inhibitors in aggressive vascular tumors. To study the role of matrix metalloproteinase in vascular tumors, we tested the antineoplastic activity of a synthetic inhibitor of matrix metalloproteinases, batimastat, on an experimental model of hemangioma, formed by murine endothelioma cells transformed by polyoma middle-T oncogene (eEnd.1). The effect of batimastat was studied in vivo on the formation of hemorrhaging, cavernous hemangiomas by eEnd.1 endothelioma cells injected subcutaneously in nude mice and on the angiogenic response induced by an endothelioma cell supernatant embedded in a pellet of reconstituted basement membrane (Matrigel). The effect of batimastat was investigated in vitro on endothelial cell proliferation, motility, and invasion of a layer of Matrigel. Daily treatment with batimastat (30, 3, and 0.3 mg/kg at the site of eEnd.1 cell injection) inhibited tumor growth, with increased doubling time. The carboxamide derivative of batimastat, BB-...Continue Reading

Citations

Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·A W GriffioenG Groenewegen
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·C PronteraD Rotilio
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Pornchai O-CharoenratSuzanne Eccles
Mar 1, 1996·Clinical & Experimental Metastasis·J G ConwayG M McGeehan
May 12, 2001·Pathology Oncology Research : POR·A John, G Tuszynski
Mar 24, 2004·Critical Reviews in Oncology/hematology·Elise LambertEmmanuelle Petitfrère
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Taraboletti, R Giavazzi
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J LeeW Orr
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D C Talbot, P D Brown
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BurkeF R Balkwill
Feb 13, 2001·Critical Reviews in Oncology/hematology·R Giavazzi, G Taraboletti
Feb 27, 2003·Critical Reviews in Oncology/hematology·Ian ChauDavid Cunningham
Mar 12, 2004·Critical Reviews in Oncology/hematology·Alessandro MorabitoGiampietro Gasparini
Mar 3, 1998·Critical Reviews in Oncology/hematology·A Ahmad, I R Hart
Nov 20, 1998·Breast Cancer Research and Treatment·C BenaudE W Thompson
Mar 5, 1999·Breast Cancer Research and Treatment·P D Brown
Oct 1, 1996·Journal of Hematotherapy·A Ahmad, I R Hart
Feb 16, 2006·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Jack C WeiRichard S Baker
Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K D MillerG W Sledge
Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Sep 14, 2001·Current Opinion in Oncology·B Fingleton, L M Matrisian
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Shoshana Greenberger, Joyce Bischoff
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P HenrietY A Declerck
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P D Brown
Mar 24, 1998·Annual Review of Medicine·B R Zetter
Jun 22, 2000·Biochemical and Biophysical Research Communications·H Wang, J A Keiser
Jun 13, 2001·Biochemical and Biophysical Research Communications·M A LafleurD R Edwards
Aug 29, 2013·Cellular and Molecular Life Sciences : CMLS·Christian Ries
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FangM A Moses
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Hui HuaYangfu Jiang
Dec 1, 2001·Expert Opinion on Biological Therapy·T G Zogakis, S K Libutti
Nov 4, 2000·Expert Opinion on Investigational Drugs·S R Bramhall
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·S L Raza, L A Cornelius

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