Inhibition of angiotensin-converting enzyme reduces rat liver reperfusion injury via bradykinin-2-receptor

The Journal of Surgical Research
Hendrik FreiseHans-Ullrich Spiegel

Abstract

Bradykinin is both a potent vasodilatator and a central inflammatory mediator. Similar to findings in myocardial reperfusion injury, bradykinin might mediate the protective effects of angiotensin-converting enzyme (ACE) inhibition after liver ischemia via increased bradykinin-2-receptor (B-2) stimulation. On the other hand, B-2-inhibition has been shown to reduce liver reperfusion injury. This study was designed to investigate the role of Bradykinin in hepatic reperfusion injury. Twenty eight rats were allocated randomly to Sham procedure (Sham), 30-min normothermic ischemia (ischemia), ischemia with Ramiprilat (ACE-I), or ischemia with Ramiprilat and B-2-inhibitor HOE 140 (ACE-I+B-2-I). Liver microcirculation and leukocyte adherence were investigated using intravital microscopy 30 min after reperfusion (n = 7 per group). In addition, serum activities of AST and ALT were measured for 7 days (n = 28). Ischemia was associated with a loss of perfused sinusoids, sinusoidal vasoconstriction, and a reduction in microvascular blood flow. Permanent leukocyte adherence increased both in sinusoids and in postsinusoidal venoles. ACE-I restored sinusoidal perfusion, normalized vasoregulation, maintained sinusoidal blood flow, and inhibited...Continue Reading

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Citations

Apr 2, 2008·Critical Care Medicine·Araní Casillas-RamirezCarmen Peralta
Feb 4, 2011·Digestive Diseases and Sciences·Yavuz BeyazitIbrahim C Haznedaroglu
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Luciano R MendonçaCarlos E Piccinato
Feb 13, 2007·The Journal of Surgical Research·Ralf BahdeHans-Ullrich Spiegel
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Nov 24, 2016·Shock·Elio AntonucciSabino Scolletta
Feb 2, 2011·Shock·Diamantino Ribeiro SalgadoJean-Louis Vincent
Oct 14, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Esam O KamelFares E M Ali
May 23, 2009·Annals of Plastic Surgery·Hamidreza Pazoki-ToroudiAlireza Firooz
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tugrul PurnakErsan Ozaslan
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Afaf S OsmanMahmoud M Kamel

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