Abstract
Bradykinin is both a potent vasodilatator and a central inflammatory mediator. Similar to findings in myocardial reperfusion injury, bradykinin might mediate the protective effects of angiotensin-converting enzyme (ACE) inhibition after liver ischemia via increased bradykinin-2-receptor (B-2) stimulation. On the other hand, B-2-inhibition has been shown to reduce liver reperfusion injury. This study was designed to investigate the role of Bradykinin in hepatic reperfusion injury. Twenty eight rats were allocated randomly to Sham procedure (Sham), 30-min normothermic ischemia (ischemia), ischemia with Ramiprilat (ACE-I), or ischemia with Ramiprilat and B-2-inhibitor HOE 140 (ACE-I+B-2-I). Liver microcirculation and leukocyte adherence were investigated using intravital microscopy 30 min after reperfusion (n = 7 per group). In addition, serum activities of AST and ALT were measured for 7 days (n = 28). Ischemia was associated with a loss of perfused sinusoids, sinusoidal vasoconstriction, and a reduction in microvascular blood flow. Permanent leukocyte adherence increased both in sinusoids and in postsinusoidal venoles. ACE-I restored sinusoidal perfusion, normalized vasoregulation, maintained sinusoidal blood flow, and inhibited...Continue Reading
References
Sep 1, 1991·Journal of Cardiovascular Pharmacology·W H van GilstH Wesseling
May 1, 1991·American Heart Journal·K Przyklenk, R A Kloner
Sep 1, 1987·Anesthesia and Analgesia·E DelvaA Lienhart
Sep 1, 1995·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H U SpiegelM Langer
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AnthuberK Messmer
Apr 20, 1999·Circulation·T BenzingR Busse
Jul 16, 1999·Hypertension·X P YangO A Carretero
Oct 26, 1999·Transplantation·H N SankaryJ W Williams
May 26, 2001·Transplantation·H MasukoS Todo
Jun 8, 2001·Journal of Cardiovascular Pharmacology·G Ertl, K Hu
Feb 6, 2002·Circulation·Maria E Marin-CastañoJean-Loup Bascands
Dec 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hartmut Jaeschke
Feb 1, 2003·Andrologia·A Blaukat
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Daniel PalmesHans-Ullrich Spiegel
Nov 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K K Veeravalli, A Akula
Dec 10, 2003·Medicine·Jean HenrionFrançis R Heller
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenji OkajimaMasakazu Mori
Jul 29, 2004·Transplantation·Raghu VaradarajanCliona O'Farrelly
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luping GuoGavin E Arteel
Feb 17, 2005·Digestive Diseases and Sciences·Kazuhisa ArakawaYasuo Morishita
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Luciana Gioli-PereiraMaria Kouyoumdjian
Citations
Apr 2, 2008·Critical Care Medicine·Araní Casillas-RamirezCarmen Peralta
Feb 4, 2011·Digestive Diseases and Sciences·Yavuz BeyazitIbrahim C Haznedaroglu
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Luciano R MendonçaCarlos E Piccinato
Feb 13, 2007·The Journal of Surgical Research·Ralf BahdeHans-Ullrich Spiegel
Feb 27, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Susagna Padrissa-AltésJoan Roselló-Catafau
Jul 21, 2010·The British Journal of Surgery·R Bahde, H-U Spiegel
Apr 15, 2014·Clinical Science·Mayra A PaioMarcia R Nagaoka
Feb 17, 2017·Genetic Testing and Molecular Biomarkers·Ahmet TayKemalettin Ozden
Nov 24, 2016·Shock·Elio AntonucciSabino Scolletta
Feb 2, 2011·Shock·Diamantino Ribeiro SalgadoJean-Louis Vincent
Oct 14, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Esam O KamelFares E M Ali
May 23, 2009·Annals of Plastic Surgery·Hamidreza Pazoki-ToroudiAlireza Firooz
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tugrul PurnakErsan Ozaslan
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Afaf S OsmanMahmoud M Kamel