Inhibition of angiotensin-converting enzyme modulates structural and functional adaptation to loop diuretic-induced diuresis

Kidney International
F X BeckW Pfaller

Abstract

The roles of elevated cell sodium concentrations and the angiotensin-aldosterone system (AAS) in the structural and functional adaptation of the distal tubule and collecting duct system to a chronic increase of sodium delivery were examined using electron microprobe and quantitative morphologic/stereologic analyses. Studies were performed on rats given the loop diuretic torasemide acutely (20 min) or chronically (12 days), either alone or in combination with the angiotensin-converting enzyme (ACE) inhibitor, enalapril. In the sodium-absorbing cells of the distal tubule and cortical collecting duct-that is, in distal convoluted tubule (DCT), connecting tubule (CNT) and principal cells-an acute increase in sodium delivery caused a significant rise in intracellular sodium concentration and rubidium uptake, the latter an index of in vivo Na,K(Rb)-ATPase activity. The elevated cell sodium concentrations returned to, or close to, control values during chronic torasemide treatment. Intracellular rubidium concentrations, measured after a 30-second rubidium exposure, were not different from controls in DCT and CNT cells but were still higher in principal cells. Since, however, the distribution space for rubidium was significantly increa...Continue Reading

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Citations

Apr 8, 1998·Current Opinion in Nephrology and Hypertension·M FrancoJ Herrera-Acosta
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Robert W HunterJohn J Mullins
Apr 4, 2008·American Journal of Physiology. Renal Physiology·Alessandra CantoneTong Wang
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Jul 13, 2000·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·L H McBrideK M Kinter
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Jul 15, 2000·American Journal of Physiology. Renal Physiology·A MonroyG Gamba
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Joseph G AbdallahDavid H Ellison

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