PMID: 6165995Jan 1, 1981Paper

Inhibition of antigen-induced proliferation of T cells from radiation-induced bone marrow chimeras by a monoclonal antibody directed against an Ia determinant on the antigen-presenting cell

Proceedings of the National Academy of Sciences of the United States of America
D L Longo, R H Schwartz

Abstract

Chimeric B10.A T cells that had matured in a (B10.A X B10.Q)F1 environment acquired the ability to respond to poly(Glu56Lys35Phe9) (GL pi), an antigen to which the B10.A mouse is a nonresponder. The response of the chimeric B10.A T cells was initiated by GL phi on responder B10.Q antigen-presenting cells (APC) but not by GL phi on nonresponder B10.A APC. Similarly, chimeric B10.Q T cells that had matured in a (B10.A X B10.Q)F1 environment acquired the ability to respond to poly(Glu60Ala30Tyr10) (GAT) when the antigen was presented on responder B10.A APC, but not when GAT was presented on nonresponder B10.Q APC. No syngeneic haplotype preference was observed for either antigen. These interactions between H-2 nonidentical T cells and APC were inhibited by anti-H-2 antisera and a monoclonal anti-Ia antibody directed against the APC but not by such antibodies when they were directed against the T cell. These data suggest that, when they develop in a responder chimeric environment, genotypic nonresponder T cells become responders by acquiring receptors that allow them to recognize responder I region products on the surface of APC. Furthermore, the data demonstrate that the site of action of the blocking effects of the anti-Ia antibo...Continue Reading

References

Feb 1, 1975·The Journal of Experimental Medicine·H BoehmerM Nabholz
Jan 1, 1977·Immunological Reviews·D W ThomasE M Shevach
Dec 1, 1979·The Journal of Experimental Medicine·I F McKenzieH I Kohn
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C S DavidJ A Frelinger

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Citations

Aug 9, 1988·Journal of Immunological Methods·J H Van den ElsenW B Van den Berg
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D FaustmanJ Davie
Nov 1, 1981·The Journal of Experimental Medicine·L H GlimcherR H Schwartz
Apr 1, 1982·The Journal of Experimental Medicine·H Y TseD L Longo
Jan 1, 1982·Immunological Reviews·D A ShackelfordJ L Strominger

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