PMID: 40391Aug 1, 1979

Inhibition of apomorphine-induced climbing in mice by cholinergic drugs and neuroleptics

Acta Pharmacologica Et Toxicologica
J B Lassen

Abstract

Apomorphine (ap) was administered subcutaneously to mice kept in individual cages. Ap elicited an abnormal vertical climbing behaviour. The muscarinomimetics physostigmine and oxotremorine as well as the neuroleptics clozapine and haloperidol inhibited the climbing produced by ap 1 mg/kg. A small inactive dose of physostigmine potentiated the effect of clozapine but not that of haloperidol. The anticholinergic atropine antagonized the effect of physostigmine, oxotremozine, clozapine and haloperidol. The climbing behaviour produced by ap is presumably due to stimulation of dopamine receptors and this effect can be antagonized either by blockade of dopamine receptors or by activation of muscarinic receptors. Some lines of evidence suggest that the ap-inhibitory effect of clozapine may be partly due to a muscarinomimetic effect.

References

Citations

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May 1, 1976·Journal of Clinical Pharmacology·G Chouinard, L Annable
Apr 1, 1976·European Journal of Pharmacology·A J PuechJ R Boissier
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Related Concepts

Antipsychotic Effect
Cholinergic Agents
Behavior, Animal
Assay OF Haloperidol
Clozapine
Atropine
Atropinum, atropine
Oxotremorine
Haloperidol
Antipsychotic Agents

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