Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and Chinese hamster lung fibroblasts

Toxicology and Applied Pharmacology
T W RobisonH J Forman

Abstract

The ability of nordihydroguaiaretic acid (NDGA) to inhibit arachidonic acid (AA) release from rat alveolar macrophages treated with t-butyl hydroperoxide (tBOOH) or from Chinese hamster lung fibroblasts (V79 cells) treated with linoleic acid hydroperoxide (LOOH) was examined. Treatment of alveolar macrophages with 100 microM tBOOH significantly increased arachidonic acid release and its conversion to metabolites. Pretreatment of macrophages with NDGA (greater than or equal to 2.5 microM) inhibited the release of AA and its subsequent metabolism following addition of tBOOH. Treatment of V79 cells with 1 microM LOOH stimulated the release of AA. Pretreatment with either 1 or 10 microM NDGA prior to the addition of LOOH inhibited the release of AA. A23187 (2 microM)-stimulated release of AA from V79 cells was less sensitive to NDGA inhibition. Pretreatment with 10 microM NDGA, but not with 1 microM NDGA, inhibited A23187-stimulated release of AA. PLA2-dependent hydrolysis of micelle preparations of disaturated phosphatidylcholine was not inhibited by NDGA. Previous studies have suggested that the addition of peroxides alters cells by inducing lipid peroxidation so that the action of phospholipases upon their membranes is enhanced....Continue Reading

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Citations

Apr 8, 2003·European Journal of Pharmacology·Miriam Alvarez-GuerraRicardo P Garay
Jan 1, 1997·Free Radical Biology & Medicine·Y J SuzukiA Sevanian
May 20, 1999·Annual Review of Pharmacology and Toxicology·T P DaltonA Puga
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Feb 4, 1999·Endothelium : Journal of Endothelial Cell Research·J A HollandL M Ziegler
Oct 24, 2019·Current Cancer Drug Targets·Geraldine Sandana Mala JohnSuresh Kumar Rayala

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