Inhibition of avian osteoclast bone resorption by monoclonal antibody 121F: a mechanism involving the osteoclast free radical system

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
P Collin-OsdobyP Osdoby

Abstract

Osteoclasts generate high levels of superoxide anions during bone resorption that contribute to the degradative process, although excessive levels of this free radical may be damaging. One mechanism for their removal is via superoxide dismutase (SOD), a protective superoxide scavenging enzyme. We have previously described a novel developmentally regulated 150 kDa plasma membrane glycoprotein of avian osteoclasts which is reactive with the osteoclast-specific monoclonal antibody (Mab) 121F and is related immunologically, biochemically, and in protein sequence to mitochondrial Mn2+/Fe2+ SOD. We hypothesized that this unusual osteoclast surface component may be involved in protection against superoxides generated during active bone resorption. Increasing concentrations of monovalent Fab fragments prepared from Mab 121F, but not those from another antiosteoclast Mab designated 29C, markedly inhibited both bone particle and bone pit resorption by avian osteoclasts, while reducing tartrate-resistant acid phosphatase activity and causing the morphological contraction of osteoclasts on bone. Thus, the SOD-related membrane antigen may be essential for osteoclast bone resorption. Osteoclast superoxide production, monitored kinetically by...Continue Reading

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Citations

Mar 14, 2002·Biochemical and Biophysical Research Communications·Hiroshi NakagawaKazuo Nagai
Jan 15, 2014·BoneKEy Reports·Celeste J HamiltonSophie A Jamal
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P Collin-OsdobyP Osdoby
Jan 12, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A JamalC J Hamilton
Jan 3, 2012·Current Osteoporosis Reports·Sophie A Jamal, Celeste J Hamilton
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xuefeng YuPhilip Osdoby
Oct 7, 2005·Journal of Pineal Research·Mehmet TurgutSerpil Erdogan
Feb 4, 2003·Journal of Pineal Research·Daniel P CardinaliCarlos Mautalen
Feb 4, 2003·Journal of Pineal Research·Marta G LadizeskyDaniel P Cardinali

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