PMID: 6170732Nov 1, 1981Paper

Inhibition of axoplasmic transport in the optic system by kainic acid

Journal of Neurochemistry
P Gomez-RamosF E Samson

Abstract

Axoplasmic transport along the optic axons was studied after intraocular injections of kainic acid (KA). Transport of labeled material did not initiate from the eye when KA was injected simultaneously with the protein precursor [3H]proline. When KA was injected after axoplasmic transport of labeled proteins had begun, no additional radioactive material moved out of the retinal ganglion cells. However, the labeled material already present in the optic nerve at the time of KA injection continued to move, and accumulated at the nerve endings. Although KA reduces the incorporation of precursor, this effect of KA on axoplasmic transport appears to be more than a consequence of inhibition on precursor uptake or protein synthesis. Recovery from this KA action began 6 h after exposure to KA and was about 50% recovered by 36 h. The extent of the recovery remained at this level for as long as a week, which suggested a partial recovery of the ganglion cells. A second exposure to KA after the inner plexiform layer had virtually disappeared was as effective as the first exposure in preventing the appearance of transported protein in the optic nerve, suggesting a direct action of KA on the ganglion cells. We interpreted the results to indica...Continue Reading

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P Campochiaro, J T Coyle
Aug 1, 1977·Experimental Neurology·S C Specht
Oct 26, 1979·Brain Research·J W OlneyT de Gubareff
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Citations

Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·J A Sigüenza, P Gomez-Ramos
Feb 1, 1983·Experimental Eye Research·P Gómez-Ramos, C Pérez-Rico
Feb 28, 2002·The European Journal of Neuroscience·V DietzC M Bastiaanse
Dec 7, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Holk CruseJosef Schmitz
Jan 26, 2007·Acta Physiologica·H Hultborn, J B Nielsen
Dec 20, 2015·Journal of Neurophysiology·Irina A SolopovaYuri P Ivanenko
Jan 1, 1985·Journal of Neuroscience Research·R V RiccioM A Matthews
Jan 1, 1982·Journal of Neuroscience Research·P Gomez-RamosF E Samson

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