PMID: 776236Mar 1, 1976

Inhibition of bacterial agmatinase by several aliphatic diamines

Biokhimii︠a︡
V A Khramov

Abstract

About 10 amino derivatives, capable to inhibit agmatinase of Proteus vulgaris, are found. Hexamethylenediamine was found to possess the highest inhibitory effect among diamines, the inhibitory constant being 2.5 mM. The substitution of an amino group for methyl one in a diamine increased its inhibitory effect. The presence of carboxyl group in the molecule of a reagent resulted in a complete elimination of the inhibitory effect (putrescine-ornithine and cadaverine-lysine pairs were tested). The degree of inhibition was found to be pH-dependent. A supposition is made on hydrophobic character of substrate binding by the enzyme.

Related Concepts

Proteus vulgaris
Putrescine
Ureohydrolases

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