Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy

Journal of Biological Engineering
Eric Krueger, Angela C Brown

Abstract

Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study alternative therapeutics, including molecules to specifically inhibit the virulence of pathogenic bacteria. Because many of these pathogenic bacteria release protein toxins, which cause or exacerbate disease, inhibition of the activity of bacterial toxins is a promising anti-virulence strategy. In this review, we describe several approaches to inhibit the initial interactions of bacterial toxins with host cell membrane components. The mechanisms by which toxins interact with the host cell membrane components have been well-studied over the years, leading to the identification of therapeutic targets, which have been exploited in the work described here. We review efforts to inhibit binding to protein receptors and essential membrane lipid components, complex assembly, and pore formation. Although none of these molecules have yet been demonstrated in clinical trials, the in vitro and in vivo results presented here demonstrate their promise as novel alternatives and/or complements to traditional antibiotics.

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Citations

Oct 8, 2020·Canadian Journal of Microbiology·Arjun SukumaranJennifer Geddes-McAlister
Feb 17, 2021·Journal of Nanobiotechnology·Hervé BesançonEduard Babiychuk
Mar 28, 2021·Comprehensive Reviews in Food Science and Food Safety·Rajashri BanerjiSunil D Saroj
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·En Hyung Chang, Angela C Brown
Jul 17, 2021·Seminars in Cancer Biology·Prabodh Chander SharmaRamesh K Goyal
Aug 28, 2021·International Journal of Molecular Sciences·Alon Ben DavidRan Zichel

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Methods Mentioned

BETA
transfection
bronchoalveolar lavage

Software Mentioned

Ply

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