Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate

Biochemical and Biophysical Research Communications
H S CheungJ A Struve

Abstract

Basic calcium phosphate crystals control the traverse of cells from the Go/G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum-induced thymidine incorporation and c-fos transcription.

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Citations

Dec 1, 1991·Revue médicale de la Suisse romande·P PancaldiH Ott
Dec 21, 2000·Current Rheumatology Reports·H S Cheung
May 15, 2003·Current Rheumatology Reports·Eamonn S Molloy, Geraldine M McCarthy
Jan 17, 2002·Current Rheumatology Reports·H S Cheung
Nov 4, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tim ScharnweberMaria Elisabete V Costa
Jul 27, 2006·Arthritis and Rheumatism·Herman S CheungAndrzej Wierzbicki
Jul 1, 2017·The Open Rheumatology Journal·Yubo SunEdward N Hanley
Jun 3, 2000·American Journal of Physiology. Renal Physiology·R M KokaJ C Lieske
Nov 1, 1993·Arthritis and Rheumatism·H E KrugH S Cheung
Feb 10, 2007·The Journal of Organic Chemistry·Petri A TurhanenJouko J Vepsäläinen

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