Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutions

Homeopathy : the Journal of the Faculty of Homeopathy
J Sainte-Laudy, P Belon

Abstract

At the beginning of this series of experiments we were looking for a model based on the use of purified commercially available compounds based on a fully described and accepted pharmacological model to study of the biological effect of high dilutions. Negative feedback induced by histamine, a major pro-inflammatory mediator, on basophils and mast cells activation via an H2 receptor me these criteria. The simplest way of measuring basophil activation in the early 1980's was the human basophil activation test (HBDT). Our major goal was first to study the biological effect of centesimal histamine dilutions beyond the Avogadro limit, on the staining properties of human basophils activated by an allergen extract initially house dust mite, then an anti-IgE and N-formyl-Met-Leu-Phe (fMLP). Technical development over the 25 years of our work led us to replace the manual basophil counting by flow cytometry. The main advantages were automation and observer independence. Using this latter protocol our aim was to confirm the existence of this phenomenon and to check its specificity by testing, under the same conditions, inactive analogues of histamine and histamine antagonists. More recently, we developed an animal model (mouse basophils) ...Continue Reading

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Citations

Apr 7, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Christopher Johnson
Jan 21, 2014·Homeopathy : the Journal of the Faculty of Homeopathy·Paolo BellaviteAnita Conforti
Jan 21, 2014·Homeopathy : the Journal of the Faculty of Homeopathy·Paolo BellaviteAnita Conforti
Mar 20, 2014·BMC Complementary and Alternative Medicine·Marta MarzottoPaolo Bellavite
Apr 30, 2013·Homeopathy : the Journal of the Faculty of Homeopathy·Francis Beauvais
Apr 30, 2013·Homeopathy : the Journal of the Faculty of Homeopathy·Prenitha Naidoo, Janice Pellow
May 10, 2011·Complementary Therapies in Medicine·Salvatore Chirumbolo
Dec 1, 2009·Homeopathy : the Journal of the Faculty of Homeopathy·Peter Fisher
Dec 19, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Leoni Villano Bonamin, Paolo Bellavite
Dec 19, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Bernard Poitevin
May 24, 2016·Homeopathy : the Journal of the Faculty of Homeopathy·Debora OliosoPaolo Bellavite
Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Leoni V BonaminLucienne C Martini
Aug 17, 2016·The Journal of Allergy and Clinical Immunology·Kaori MukaiStephen J Galli
Jun 19, 2010·Human & Experimental Toxicology·Paolo BellaviteMarta Marzotto
Jun 19, 2010·Human & Experimental Toxicology·Peter Fisher
Apr 28, 2012·Medicine, Health Care, and Philosophy·Lex RuttenMichel van Wassenhoven
Jan 30, 2015·The Cochrane Database of Systematic Reviews·Robert T MathiePeter Fisher
Mar 23, 2017·Homeopathy : the Journal of the Faculty of Homeopathy·Francis Beauvais
Nov 20, 2021·Homeopathy : the Journal of the Faculty of Homeopathy·Raj Kumar ManchandaRobbert van Haselen

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