Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Sandra VillanuevaCarlos P Vio

Abstract

Recovery from acute renal failure (ARF) requires the replacement of injured cells by new cells that are able to restore tubule epithelial integrity. We have recently described the expression of nephrogenic proteins [Vimentin, neural cell adhesion molecule, basic fibroblast growth factor (bFGF), Pax-2, bone morphogen protein-7, Noggin, Smad 1-5-8, p-Smad, hypoxia-inducible factor-1alpha, vascular endothelial growth factor], in a time frame similar to that observed in kidney development, after ischemic ARF induced in an ischemia-reperfusion (I/R) model. Furthermore, we show that bFGF, a morphogen involved in mesenchyme/epithelial transition in kidney development, induces a reexpression of morphogenic proteins in an earlier time frame and accelerates the recovery process after renal damage. Herein, we confirm that renal morphogenes are modulated by bFGF and hypothesized that a decrease in bFGF receptor 2 (bFGFR2) levels by the use of antisense oligonucleotides diminishes the expression of morphogenes. Male Sprague-Dawley rats submitted to ischemic injury were injected with 112 microg/kg bFGFR2 antisense oligonucleotide (bFGFR2-ASO) followed by reperfusion. Rats were killed, and the expression of nephrogenic proteins and renal mark...Continue Reading

References

Sep 1, 1991·Differentiation; Research in Biological Diversity·A O PerantoniC L Williams
Jan 1, 1985·Pflügers Archiv : European journal of physiology·S I HelmanL M Baxendale
Jun 1, 1987·Kidney International·C P Vío, C D Figueroa
Jul 1, 1994·Brain Pathology·K H PlateW Risau
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·A O PerantoniI Karavanova
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·H SakuraiS K Nigam
Sep 14, 1999·The American Journal of Physiology·M AbbateJ V Bonventre
Oct 24, 2000·Kidney International·J B Kopp
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Carlos P VioNicholas R Ferreri
Nov 28, 2001·The Journal of Laboratory and Clinical Medicine·R OberbauerG Mayer
Jan 11, 2002·Developmental Biology·Sandra VillanuevaRoberto Mayor
Feb 19, 2002·Kidney International·Qais Al-Awqati, Juan A Oliver
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jens Lundbaek AndersenPeter Bie
Apr 23, 2002·Kidney International·Frank StrutzEric G Neilson
Nov 6, 2002·Annals of Internal Medicine·Matthew L Esson, Robert W Schrier
Feb 15, 2003·JAMA : the Journal of the American Medical Association·Naveen SingriMurray L Levin
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kay-Dietrich WagnerHolger Scholz
Jul 3, 2003·Seminars in Nephrology·Ravindra L Mehta
Jul 23, 2003·The Korean Journal of Internal Medicine·Byung-Soo Kim, Michael S Goligorsky
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Paul B Freeburg, Dale R Abrahamson
Nov 1, 2003·Thrombosis Research·Nicholas R FerreriMairead A Carroll
Dec 3, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zixi ChengDavid Gozal
Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Norbert H Lameire, Raymond Vanholder
Oct 1, 2004·American Journal of Physiology. Cell Physiology·Rina TakamiyaNaoyuki Taniguchi
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qi CaiMaurice Burg
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaNaoyuki Hayashi
Jul 29, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sandra VillanuevaCarlos P Vio

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Citations

Oct 1, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Parnell C MattisonPatricio E Ray
Jul 23, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kitman WaiPatricio E Ray
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Motoko Yanagita
Nov 16, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin LeducSylvain Chemtob
May 19, 2012·PloS One·Aleksandr KirovIgor Prudovsky
Feb 23, 2013·Journal of the American Society of Hypertension : JASH·Alejandro R Chade, Nicholas Stewart
Aug 17, 2012·Kidney International·Jianlin ChenChristopher Y Lu
Mar 13, 2015·Proteomics. Clinical Applications·Sofia PerazzoPatricio E Ray
Jun 17, 2011·Clinical Science·Sandra VillanuevaCarlos P Vio
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Alfonso EirinLilach O Lerman
Jul 2, 2010·American Journal of Physiology. Renal Physiology·C VinsonneauJ-P Haymann
Apr 24, 2020·Frontiers in Pharmacology·Lian-Cheng DengJin-San Zhang
Nov 29, 2013·American Journal of Physiology. Renal Physiology·Sandra VillanuevaCarlos P Vio
Mar 31, 2021·Epigenetics : Official Journal of the DNA Methylation Society·John K WienckeKarl T Kelsey
Jun 17, 2021·Cell and Tissue Research·Nicola WannerFriedrich Koch-Nolte

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