Inhibition of biological activity of mouse beta-nerve growth factor by monoclonal antibody

Science
S L WarrenK E Neet

Abstract

A continuous hybrid cell line was derived that secretes monoclonal antibody capable of inhibiting the biological activity of mouse beta-nerve growth factor (beta-NGF). Results obtained with monovalent fragments indicate that the monoclonal antibody inhibits activity by interfering with the direct interaction between beta-NGF and the cell membrane receptor rather than by precipitating the dimeric form of beta-NGF. This monoclonal antibody binds to an antigenic determinant common to mouse beta-NGF, snake venom (Naja naja) beta-NGF, and human beta-NGF. These antibodies should provide specific molecular probes for a variety of studies of nerve growth factor including its tissue distribution and mechanism of action.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K SudaH Thoenen
Nov 1, 1977·Analytical Biochemistry·R W StachB M Stach
Jun 23, 1976·Biochimica Et Biophysica Acta·G S BaileyC A Vernon
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S P BanerjeeL A Greene
Sep 15, 1973·Journal of Molecular Biology·F W Studier
Dec 1, 1969·Biochemistry·A P SmithE M Shooter
Mar 1, 1970·Experimental Cell Research·E L Fenton
Apr 1, 1970·Experimental Cell Research·K Horibata, A W Harris
Jan 1, 1980·Journal of Neurochemistry·G P Harper, H Thoenen

❮ Previous
Next ❯

Citations

May 20, 1996·Biotechnology and Bioengineering·R H LiF T Gentile
Mar 1, 1994·Journal of Neuroscience Research·J NanduriK E Neet
Dec 1, 1981·In Vitro·R H Kennett
Sep 1, 1985·Molecular Immunology·J G SteeleD Rathjen
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J SiigurM Saarma
Mar 17, 1983·The New England Journal of Medicine·K DeSchryver-KecskemetiL O'Neal
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A ZimmermannE M Shooter
Jan 1, 1982·Journal of Neuroscience Research·A Baron-Van EvercoorenM E Dubois-Dalcq
Jan 1, 1989·Journal of Neuroscience Research·D WattersI Hendry
Aug 31, 2006·Journal of the American Chemical Society·Timothy LeongDavid H Gracias
Dec 15, 2005·Nano Letters·Munish ChananaSilke Krol
Sep 20, 2008·Chemistry of Materials : a Publication of the American Chemical Society·Adam WinklemanGeorge M Whitesides

❮ Previous
Next ❯

Related Concepts

Related Feeds