Inhibition of blood group antibodies by soluble substances.

Immunohematology
Karen M ByrneWilly A Flegel

Abstract

The presence of multiple alloantibodies or an antibody to a high-prevalance antigen in a patient sample can pose challenges in antibody identification. The pattern of reactivity seen on an antibody panel may show various strengths of reactivity by different methods of testing or same strength of reactivity at one or more phases of testing. To ensure proper identification, multiple investigative tools may be used. We review one of these methods-inhibition by soluble substances-which has become an expansion of our toolbox within the past 10 years. Alloantibodies can be inhibited using specific soluble substances. These soluble substances occur naturally in various fluids or can be manufactured. When a patient sample contains multiple antibodies, clinically significant or not, inhibition of one may help determine specificities of others. Specific inhibition of a particular antibody will also help to confirm its presence. The presence of multiple alloantibodies or an antibody to a high-prevalance antigen in a patient sample can pose challenges in antibody identification. The pattern of reactivity seen on an antibody panel may show various strengths of reactivity by different methods of testing or same strength of reactivity at one ...Continue Reading

References

Sep 8, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Markus T RojewskiWilly A Flegel
Nov 30, 1940·The Journal of Experimental Medicine·E Witebsky, N C Klendshoj
Jan 5, 2014·Transfusion·Markus AnlikerChristof Weinstock
Oct 8, 2015·Clinical Lymphoma, Myeloma & Leukemia·Sandy W Wong, Raymond L Comenzo
Dec 6, 2018·Transfusion·Randall W VelliquetteConnie M Westhoff
Dec 7, 2018·Transfusion·Willy A Flegel, Stephen M Henry

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Citations

Jun 2, 2021·Transfusion·Willy A Flegel, Kshitij Srivastava

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