Inhibition of bone marrow-derived dendritic cell maturation by glabridin

International Immunopharmacology
Jee Youn KimSang-Bae Han

Abstract

Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. Glabridin inhibited lipopolysaccharide-, poly (I:C)-, or zymosan-induced phenotypic maturation of dendritic cells (DCs), as proven by the decreased expression of CD40, CD80, CD86, MHC-I, and MHC-II. Glabridin decreased the functional maturation of DCs, in that glabridin attenuated pro-inflammatory cytokine production of IL-12, IL-1β, TNF-α, and IFN-α/β, enhanced antigen capture capacity, inhibited migration to SDF-1α and MIP-3β, and impaired induction of allogenic T cell activation. We also showed that glabridin inhibited zymosan-induced inflammation in mice. As a mode of action, we showed that glabridin inhibited degradation of IκΒα/β, nuclear translocation of NF-κB p65/p50, and phosphorylation of ERK, JNK, and p38 MAPKs. Taken together, the present results show that glabridin inhibits dendritic cell maturation by blocking NF-κB and MAPK signalings.

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Citations

Nov 20, 2012·International Immunopharmacology·Jee Youn KimSang-Bae Han
Nov 4, 2015·International Immunopharmacology·Moo Rim KangJong Soon Kang
Jun 15, 2016·Current Treatment Options in Rheumatology·Ryu WatanabeCornelia M Weyand
Jun 13, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyung Sook KimSang-Bae Han
Jul 16, 2013·Fitoterapia·Charlotte SimmlerShao-Nong Chen
Jun 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyung Sook KimSang-Bae Han
Feb 3, 2011·Immune Network·Hyung Sook KimSang-Bae Han
Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
Feb 3, 2021·Journal of Microbiology and Biotechnology·Chijian ZhangTinggang He

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