PMID: 9163342Apr 15, 1997Paper

Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors

The Biochemical Journal
K M BottomleyW H Johnson

Abstract

N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a predominant ARGSVIL sequence with an additional ADLEX sequence. Production of the ARGSVIL-containing fragments has been attributed to the action of a putative proteinase, aggrecanase. The minor sequence (ADLEX) corresponds to a new reported cleavage product; comparison of this sequence with the available partial sequence of bovine aggrecan indicates that this is the product of a cleavage occurring towards the C-terminus of the protein. Matrix metalloproteinase (MMP) inhibitors inhibited aggrecan loss from bovine nasal explants incubated in the presence of recombinant human interleukin 1alpha. A strong correlation between inhibition of aggrecan metabolism and inhibition of stromelysin 1 (MMP 3) (r=0.93) suggests a role for stromelysin or a stromelysin-like enzyme in cartilage aggrecan metabolism. However, the compounds were approx. 1/1000 as potent in inhibiting aggrecan loss from the cartilage explants as they were in inhibiting stromelysin. There was little or no correlation between inhibition of aggrecan metabolism and inhibition of gelatinase B (MMP 9) or inhibition of collage...Continue Reading

Citations

Nov 27, 2004·Osteoarthritis and Cartilage·Kotaro SugimotoMasaaki Takahashi
Feb 10, 2010·Chemistry & Biology·Haruhide KimuraMasayuki Takizawa
Nov 19, 2009·Arthritis Research & Therapy·Christopher G WilsonMarc E Levenston
Jul 27, 2001·Clinical and Experimental Immunology·P J MiddelhovenD Roos
Nov 2, 2017·Expert Opinion on Drug Discovery·Yue ZhongJin-Ao Duan
Apr 26, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth W FishbeinRichard G Spencer
Jun 18, 1998·Journal of Enzyme Inhibition·K M BottomleyD S Walter
Aug 2, 2003·The Journal of Biological Chemistry·Michael A PrattaElizabeth C Arner
Sep 27, 2013·International Journal of Immunopathology and Pharmacology·L Lipari, A Gerbino
May 16, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Christopher B LittleBruce Caterson

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