PMID: 6540739Aug 1, 1984Paper

Inhibition of bovine platelet function by T-2 toxin, HT-2 toxin, diacetoxyscirpenol and deoxynivalenol

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P K Chan, P A Gentry

Abstract

The aggregation of bovine platelets suspended in homologous plasma is inhibited in the presence of T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) or deoxynivalenol (DON) when either collagen or ADP is used as the stimulatory agent for aggregation. For each of the mycotoxins the degree of inhibition is dependent on the amount of trichothecene present in the platelet suspension but is not dependent on the time of exposure of the platelets to the toxin. For both ADP- and collagen-stimulated platelets, the order of potency of inhibition is T-2 toxin greater than HT-2 toxin greater than DAS greater than DON. A significant (P less than 0.01) dose-dependent decrease was also observed in the amount of the thromboxane B2 released from collagen-stimulated platelets in the presence of each of the mycotoxins.

Citations

Jan 1, 1987·Veterinary Research Communications·P A GentryM L Ross
Mar 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R GuntherC J Mirocha
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G S Bondy, P A Gentry
Jan 1, 1989·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G S BondyP A Gentry
Jun 15, 1985·Toxicology and Applied Pharmacology·D J Wilson, P A Gentry
Sep 3, 2004·Toxicology Letters·D Parent-Massin
Jan 1, 1993·Drug Metabolism Reviews·B Yagen, M Bialer
Dec 24, 1997·Critical Reviews in Food Science and Nutrition·R B Pegg, F Shahidi
Aug 16, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler

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