PMID: 6407532Jul 12, 1983Paper

Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids

Biochimica Et Biophysica Acta
H OsamaH Umezawa

Abstract

The activities of rat brain prostaglandin D synthetase and swine brain prostaglandin D2 dehydrogenase were inhibited by some saturated and unsaturated fatty acids. Myristic acid was most potent among saturated straight-chain fatty acids so far tested. The IC50 values of this acid were 80 microM for prostaglandin D synthetase and 7 microM for prostaglandin D2 dehydrogenase, respectively. Little inhibition was found with methyl myristate and myristyl alcohol. The IC50 values of these derivatives were more than 200 microM for both enzymes, suggesting that the free carboxyl group was essential for the inhibition. The effects of cis double bond structure of fatty acids on the inhibition potency were examined by the use of the carbon 18 and 20 fatty acids. The inhibition potencies for both enzymes increased with the number of cis double bonds; the IC50 values of stearic, oleic, linoleic and linolenic acid were, respectively, more than 200, 60, 30 and 30 microM for prostaglandin D synthetase, and 20, 10, 8.5 and 7 microM for prostaglandin D2 dehydrogenase. Arachidonic acid also inhibited the activities of both enzymes with respective IC50 values of 40 microM for prostaglandin D synthetase and 3.9 microM for prostaglandin D2 dehydrogen...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanH Sprecher
Jan 1, 1977·Prostaglandins·F F SunJ C McGuire
Nov 15, 1975·Biochemical Pharmacology·J RobakR Gryglewski
Jul 1, 1976·Prostaglandins·W P Kingston, M W Greaves
Dec 20, 1976·Biochimica Et Biophysica Acta·E Christ-HazelhofD A Van Dorp
Jun 1, 1982·Archives of Biochemistry and Biophysics·T WatanabeO Hayaishi
Nov 30, 1982·Biochemical and Biophysical Research Communications·R UenoO Hayaishi
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R UenoO Hayaishi

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Citations

Jun 1, 1985·Prostaglandins·J P CoddeR Vandongen
Dec 18, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yohko FujimotoSatoru Sakuma
Sep 27, 2016·Archives of Biochemistry and Biophysics·Akira HaraKoji Yashiro
Jul 22, 2010·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·R A KnazekJ Costa

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