PMID: 9187104Jun 1, 1997Paper

Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole

Cancer Research
P C de JongR A Blankenstein

Abstract

In about one-third of advanced breast cancers, estrogen deprivation causes tumor regression. Estrogen concentrations in tumor tissue seem to depend largely on local production. The aromatase enzyme complex is thought to be the key enzyme in this respect. In the present study, the effect of the new third-generation nonsteroidal aromatase inhibitor vorozole (Rivizor) on tumor tissue aromatase activity and estrogen concentrations was evaluated. During 7 days preceding mastectomy, 11 postmenopausal breast cancer patients were treated with 2.5 mg of vorozole once daily. Eight patients could be evaluated. Intratumoral aromatase activity and estrone and estradiol levels were measured and compared to the values of nine untreated postmenopausal breast cancer patients. In treated patients, median tissue aromatase activity was 89% lower than that in controls (P < 0.001). Similarly, median tissue estrone and estradiol concentrations were 64 and 80% lower, respectively, in treated patients (P = 0.001 and P < 0.05, respectively). These results support the hypothesis that depleting the tumor of estrogens, thus impairing estrogenic stimulation, is an important mechanism in the antitumor activity of aromatase inhibitors.

Citations

Dec 13, 2007·Medical Oncology·Kartikeya Pant, Udayan Dutta
Jan 29, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Jürgen Geisler
Dec 16, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Paul Chr de JongAngela M Brodie
May 15, 2002·Fertility and Sterility·Evan R Simpson
Sep 6, 2003·Steroids·Richard J Santen
May 24, 2000·The Journal of Steroid Biochemistry and Molecular Biology·J GeislerP E Lonning
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·G S Chetrite, J R Pasqualini
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·P E Lønning
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·E R Simpson
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jürgen Geisler
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·J R PasqualiniJ Botella
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·M A BlankensteinJ H Thijssen
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J R Pasqualini, G S Chetrite
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Oct 31, 1998·Breast Cancer Research and Treatment·P E Goss
Mar 4, 2003·Environmental Health Perspectives·Jürg A ZarnJosef R Schlatter
Nov 4, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Jürgen GeislerHironobu Sasano
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Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·P C de JongJ H Thijssen
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Oct 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amar Mohamed IsmailNoor Hasima
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Apr 9, 2005·Endocrine Reviews·E R SimpsonC D Clyne

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