Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex

Journal of Nanobiotechnology
Yu-Ling LinKuang-Wen Liao

Abstract

Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER) positive breast cancer in pre- and post-menopausal women. However, using tamoxifen routinely to inhibit endogenous or exogenous estrogen effects is occasionally difficult because of its potential side effects. The aim of this study is to design a local drug delivery system to encapsulate tamoxifen for observing their efficacy of skin penetration, drug accumulation and cancer therapy. A cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of tamoxifen and forming 'LPPC/TAM' for transdermal release. The cytotoxicity of LPPC/TAM was analyzed by MTT. The skin penetration, tumor growth inhibition and organ damages were measured in xenograft mice following transdermal treatment. LPPC/TAM had an average size less than 270 nm and a zeta-potential of approximately 40 mV. LPPC/TAM displayed dramatically increased the cytotoxic activity in all breast cancer cells, especially in ER-positive breast cancer cells. In vivo, LPPC drug delivery helped the fluorescent dye penetrating across the skim and accumulating rapidly in tumor area. Administration of LPPC/TAM by transdermal route inhibited about 86 % of tumor growt...Continue Reading

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Citations

Jul 20, 2018·Journal of Liposome Research·Anup JoseVenkata Vamsi Krishna Venuganti
Mar 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Candace M DaySanjay Garg
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kai-Fu ChangNu-Man Tsai
Sep 30, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X-F HuangN-M Tsai
Nov 7, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Masoud FarshbafRoya Salehi
Apr 21, 2019·The Journal of Surgical Research·Yuan-Ching ChangChien-Liang Liu

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Methods Mentioned

BETA
ELISA

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